Homo sapiens Gene: CASP5
Summary
InnateDB Gene IDBG-69591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP5
Gene Name caspase 5, apoptosis-related cysteine peptidase
Synonyms ICE(rel)III; ICEREL-III; ICH-3;
Species Homo sapiens
Ensembl Gene ENSG00000137757
Encoded Proteins
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:104994235-105023168
Strand Reverse strand
Band q22.3
Transcripts
ENST00000260315 ENSP00000260315
ENST00000393141 ENSP00000376849
ENST00000438448 ENSP00000396053
ENST00000444749 ENSP00000388365
ENST00000418434 ENSP00000398130
ENST00000456200 ENSP00000408455
ENST00000456094 ENSP00000415241
ENST00000526056 ENSP00000436877
ENST00000531367 ENSP00000434471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0021762 substantia nigra development
GO:0042981 regulation of apoptotic process
GO:0050727 regulation of inflammatory response
GO:0071260 cellular response to mechanical stimulus
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0072558 NLRP1 inflammasome complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
NOD-like receptor signaling pathway pathway
INOH
PID BIOCARTA
Internal ribosome entry pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.213327
RefSeq NM_001136109 NM_001136110 NM_001136112 NM_004347 XM_006718925
HUGO
OMIM
CCDS CCDS44718 CCDS44719 CCDS44720 CCDS8328
HPRD 04048
IMGT
EMBL
GenPept
RNA Seq Atlas