Version 5.4
Homo sapiens Gene: BMP4
Summary
InnateDB Gene IDBG-6966.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP4
Gene Name bone morphogenetic protein 4
Synonyms BMP2B; BMP2B1; MCOPS6; OFC11; ZYME
Species Homo sapiens
Ensembl Gene ENSG00000125378
Encoded Proteins
IDBP-6968
bone morphogenetic protein 4
IDBP-369237
bone morphogenetic protein 4
IDBP-603080
bone morphogenetic protein 4
IDBP-586888
bone morphogenetic protein 4
IDBP-588205
bone morphogenetic protein 4
IDBP-601910
bone morphogenetic protein 4
IDBP-597245
bone morphogenetic protein 4
IDBP-807899
bone morphogenetic protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5\' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:53949736-53958761
Strand Reverse strand
Band q22.2
Transcripts
ENST00000245451 ENSP00000245451
ENST00000417573 ENSP00000394165
ENST00000559087 ENSP00000453485
ENST00000558984 ENSP00000454134
ENST00000559501 ENSP00000453365
ENST00000558961 ENSP00000453691
ENST00000559642 ENSP00000453467
ENST00000558489
ENST00000609748 ENSP00000476690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
GO:0070700 BMP receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000186 activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001707 mesoderm formation
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0001958 endochondral ossification
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0003014 renal system process
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003139 secondary heart field specification
GO:0003197 endocardial cushion development
GO:0003279 cardiac septum development
GO:0003323 type B pancreatic cell development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0007281 germ cell development
GO:0007500 mesodermal cell fate determination
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0009888 tissue development
GO:0009948 anterior/posterior axis specification
GO:0010159 specification of organ position
GO:0010453 regulation of cell fate commitment
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 positive regulation of cell death
GO:0021537 telencephalon development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0030198 extracellular matrix organization
GO:0030218 erythrocyte differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0032092 positive regulation of protein binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0034504 protein localization to nucleus
GO:0035116 embryonic hindlimb morphogenesis
GO:0035990 tendon cell differentiation
GO:0035993 deltoid tuberosity development
GO:0040007 growth
GO:0042326 negative regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0045165 cell fate commitment
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitosis
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048333 mesodermal cell differentiation
GO:0048392 intermediate mesodermal cell differentiation
GO:0048593 camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048745 smooth muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050918 positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0055020 positive regulation of cardiac muscle fiber development
GO:0060113 inner ear receptor cell differentiation
GO:0060197 cloacal septation
GO:0060235 lens induction in camera-type eye
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060348 bone development
GO:0060363 cranial suture morphogenesis
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060425 lung morphogenesis
GO:0060429 epithelium development
GO:0060433 bronchus development
GO:0060438 trachea development
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060503 bud dilation involved in lung branching
GO:0060512 prostate gland morphogenesis
GO:0060548 negative regulation of cell death
GO:0060592 mammary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061149 BMP signaling pathway involved in ureter morphogenesis
GO:0061151 BMP signaling pathway involved in renal system segmentation
GO:0061155 pulmonary artery endothelial tube morphogenesis
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071893 BMP signaling pathway involved in nephric duct formation
GO:0072001 renal system development
GO:0072015 glomerular visceral epithelial cell development
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 glomerular capillary formation
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072192 ureter epithelial cell differentiation
GO:0072193 ureter smooth muscle cell differentiation
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 metanephric collecting duct development
GO:0090184 positive regulation of kidney development
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 negative regulation of glomerulus development
GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105 positive regulation of DNA-dependent DNA replication
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012 mesenchymal cell differentiation involved in renal system development
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021835
View Gene Order
ENSBTAG00000003835
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
hsa04340
Hedgehog signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
glypican_3pathway
Glypican 3 network
Cross-References
SwissProt P12644
TrEMBL H0YLW3 H0YM53 Q53XC5 U3MVU6
UniProt Splice Variant
Entrez Gene 652
UniGene Hs.68879
RefSeq NM_001202 NM_130850 NM_130851 XM_005268015
HUGO HGNC:1071
OMIM 112262
CCDS CCDS9715
HPRD 00207
IMGT
EMBL AL138479 BC020546 BX161385 BX161438 CH471061 D30751 EU518936 KF250427 M22490 U43842
GenPept AAA51835 AAC72278 AAH20546 ACB21039 AGW21692 BAA06410 CAD61876 CAD61909 EAW80628 EAW80629 EAW80630 EAW80631
RNA Seq Atlas 652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca