Version 5.4
Homo sapiens Gene: TK1
Summary
InnateDB Gene IDBG-70500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TK1
Gene Name thymidine kinase 1, soluble
Synonyms TK2
Species Homo sapiens
Ensembl Gene ENSG00000167900
Encoded Proteins
IDBP-70502
thymidine kinase 1, soluble
IDBP-758295
IDBP-759380
IDBP-760233
IDBP-762108
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:78174075-78187233
Strand Reverse strand
Band q25.3
Transcripts
ENST00000301634 ENSP00000301634
ENST00000592126
ENST00000588734 ENSP00000468425
ENST00000590862 ENSP00000468556
ENST00000590430 ENSP00000467121
ENST00000586613 ENSP00000468278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 317 experimentally validated interaction(s) in this database.
Experimentally validated
Total 317 [view]
Protein-Protein 314 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0019206 nucleoside kinase activity
GO:0042802 identical protein binding
Biological Process
GO:0001889 liver development
GO:0006139 nucleobase-containing compound metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006260 DNA replication
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009636 response to toxic substance
GO:0014856 skeletal muscle cell proliferation
GO:0016310 phosphorylation
GO:0031667 response to nutrient levels
GO:0043097 pyrimidine nucleoside salvage
GO:0044281 small molecule metabolic process
GO:0046104 thymidine metabolic process
GO:0046688 response to copper ion
GO:0048565 digestive tract development
GO:0051289 protein homotetramerization
GO:0051414 response to cortisol
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0060138 fetal process involved in parturition
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025574
View Gene Order
ENSBTAG00000007121
Not yet available
Pathways
NETPATH
REACTOME
REACT_655
Pyrimidine salvage reactions pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.624417
RefSeq NM_003258
HUGO
OMIM
CCDS CCDS11754
HPRD 01771
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca