Version 5.4
Homo sapiens Gene: CCNT2
Summary
InnateDB Gene IDBG-70567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNT2
Gene Name cyclin T2
Synonyms CYCT2
Species Homo sapiens
Ensembl Gene ENSG00000082258
Encoded Proteins
IDBP-70569
cyclin T2
IDBP-70571
cyclin T2
IDBP-386093
cyclin T2
IDBP-386094
cyclin T2
IDBP-386095
cyclin T2
IDBP-386096
cyclin T2
IDBP-386097
cyclin T2
IDBP-386098
cyclin T2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:134918235-134959342
Strand Forward strand
Band q21.3
Transcripts
ENST00000295238 ENSP00000295238
ENST00000264157 ENSP00000264157
ENST00000419781 ENSP00000404653
ENST00000446247 ENSP00000399497
ENST00000452839 ENSP00000400298
ENST00000417175 ENSP00000402512
ENST00000452521 ENSP00000387436
ENST00000438691 ENSP00000415120
ENST00000475094
ENST00000464932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026349
View Gene Order
ENSBTAG00000014158
Not yet available
Pathways
NETPATH
REACTOME
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_6256
HIV Life Cycle pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_6185
HIV Infection pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.292754 Hs.591241 Hs.743651
RefSeq NM_001241 NM_058241 XM_005263830 XM_005263832 XM_006712827
HUGO
OMIM
CCDS CCDS2174 CCDS2175
HPRD 04839
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca