Homo sapiens Gene: APOD
Summary
InnateDB Gene IDBG-70578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOD
Gene Name apolipoprotein D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000189058
Encoded Proteins
apolipoprotein D
apolipoprotein D
apolipoprotein D
apolipoprotein D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:195568702-195584205
Strand Reverse strand
Band q29
Transcripts
ENST00000343267 ENSP00000345179
ENST00000458447 ENSP00000391597
ENST00000421243 ENSP00000415235
ENST00000453131 ENSP00000393076
ENST00000463719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0036094 small molecule binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001525 angiogenesis
GO:0006006 glucose metabolic process
GO:0006629 lipid metabolic process
GO:0006810 transport
GO:0006869 lipid transport
GO:0007420 brain development
GO:0007568 aging
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014012 peripheral nervous system axon regeneration
GO:0030682 evasion or tolerance of host defense response
GO:0042246 tissue regeneration
GO:0042308 negative regulation of protein import into nucleus
GO:0042493 response to drug
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048678 response to axon injury
GO:0051895 negative regulation of focal adhesion assembly
GO:0060588 negative regulation of lipoprotein lipid oxidation
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000098 negative regulation of smooth muscle cell-matrix adhesion
GO:2000405 negative regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0022626 cytosolic ribosome
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Transport of vitamins, nucleosides, and related molecules pathway
Orphan transporters pathway
Transport of fatty acids pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001647
HUGO
OMIM
CCDS CCDS33925
HPRD 00134
IMGT
EMBL
GenPept
RNA Seq Atlas