InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOD

Summary

InnateDB Gene

IDBG-70578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOD

Gene Name

apolipoprotein D

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000189058

Encoded Proteins

IDBP-70580

apolipoprotein D

IDBP-386857

apolipoprotein D

IDBP-386858

apolipoprotein D

IDBP-386859

apolipoprotein D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:195568702-195584205

Strand

Reverse strand

Band

q29

Transcripts

ENST00000343267	ENSP00000345179
ENST00000458447	ENSP00000391597
ENST00000421243	ENSP00000415235
ENST00000453131	ENSP00000393076
ENST00000463719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0036094	small molecule binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001525	angiogenesis
GO:0006006	glucose metabolic process
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0006869	lipid transport
GO:0007420	brain development
GO:0007568	aging
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014012	peripheral nervous system axon regeneration
GO:0030682	evasion or tolerance of host defense response
GO:0042246	tissue regeneration
GO:0042308	negative regulation of protein import into nucleus
GO:0042493	response to drug
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048678	response to axon injury
GO:0051895	negative regulation of focal adhesion assembly
GO:0060588	negative regulation of lipoprotein lipid oxidation
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:1900016	negative regulation of cytokine production involved in inflammatory response
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion
GO:2000405	negative regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005783	endoplasmic reticulum
GO:0022626	cytosolic ribosome
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022548

View Gene Order

ENSBTAG00000023600

Not yet available

Pathways

NETPATH

REACTOME

REACT_23892

Transport of fatty acids pathway

REACT_22285

Transport of vitamins, nucleosides, and related molecules pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_267716

Orphan transporters pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001647

HUGO

OMIM

CCDS

CCDS33925

HPRD

00134

IMGT

EMBL

GenPept

RNA Seq Atlas