Homo sapiens Gene: RDX
Summary
InnateDB Gene IDBG-70605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDX
Gene Name radixin
Synonyms DFNB24;
Species Homo sapiens
Ensembl Gene ENSG00000137710
Encoded Proteins
radixin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:110174880-110296722
Strand Reverse strand
Band q22.3
Transcripts
ENST00000343115 ENSP00000342830
ENST00000405097 ENSP00000384136
ENST00000530749 ENSP00000437301
ENST00000528498 ENSP00000432112
ENST00000528900 ENSP00000433580
ENST00000530301 ENSP00000436277
ENST00000527537
ENST00000532461
ENST00000533961
ENST00000530131 ENSP00000432829
ENST00000530085 ENSP00000434788
ENST00000529774
ENST00000534683 ENSP00000431560
ENST00000532118 ENSP00000437140
ENST00000528556 ENSP00000434881
ENST00000533991 ENSP00000432572
ENST00000533678 ENSP00000435930
ENST00000544551 ENSP00000445826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0010628 positive regulation of gene expression
GO:0030033 microvillus assembly
GO:0045176 apical protein localization
GO:0051693 actin filament capping
GO:0061028 establishment of endothelial barrier
Cellular Component
GO:0001726 ruffle
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005925 focal adhesion
GO:0019898 extrinsic component of membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030315 T-tubule
GO:0032154 cleavage furrow
GO:0032420 stereocilium
GO:0045177 apical part of cell
GO:0051286 cell tip
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
REACTOME
Developmental Biology pathway
Axon guidance pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
KEGG
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9PQ82
UniProt Splice Variant
Entrez Gene 5962
UniGene Hs.263671 Hs.617782 Hs.733039 Hs.741211
RefSeq NM_002906 NM_001260493 NM_001260492 NM_001260495 NM_001260496 NM_001260494
HUGO HGNC:9944
OMIM 179410
CCDS CCDS8343 CCDS58174 CCDS58171 CCDS58173 CCDS58172
HPRD 01534
IMGT
EMBL AP000901 AP002788
GenPept
RNA Seq Atlas 5962