InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RDX

Summary

InnateDB Gene

IDBG-70605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDX

Gene Name

radixin

Synonyms

DFNB24

Species

Homo sapiens

Ensembl Gene

ENSG00000137710

Encoded Proteins

IDBP-70607

radixin

IDBP-293907

radixin

IDBP-587938

radixin

IDBP-583844

radixin

IDBP-584140

radixin

IDBP-590330

radixin

IDBP-603129

radixin

IDBP-589398

radixin

IDBP-593866

radixin

IDBP-601706

radixin

IDBP-588481

radixin

IDBP-585276

radixin

IDBP-593385

radixin

IDBP-598237

radixin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:110174880-110296722

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000343115	ENSP00000342830
ENST00000405097	ENSP00000384136
ENST00000530749	ENSP00000437301
ENST00000528498	ENSP00000432112
ENST00000528900	ENSP00000433580
ENST00000530301	ENSP00000436277
ENST00000527537
ENST00000532461
ENST00000533961
ENST00000530131	ENSP00000432829
ENST00000530085	ENSP00000434788
ENST00000529774
ENST00000534683	ENSP00000431560
ENST00000532118	ENSP00000437140
ENST00000528556	ENSP00000434881
ENST00000533991	ENSP00000432572
ENST00000533678	ENSP00000435930
ENST00000544551	ENSP00000445826

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0010628	positive regulation of gene expression
GO:0030033	microvillus assembly
GO:0045176	apical protein localization
GO:0051693	actin filament capping
GO:0061028	establishment of endothelial barrier

Cellular Component

GO:0001726	ruffle
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0019898	extrinsic component of membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030315	T-tubule
GO:0032154	cleavage furrow
GO:0032420	stereocilium
GO:0045177	apical part of cell
GO:0051286	cell tip
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032050

View Gene Order

ENSBTAG00000004672

Not yet available

Pathways

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.263671 Hs.617782 Hs.733039 Hs.741211

RefSeq

NM_001260492 NM_001260493 NM_001260494 NM_001260495 NM_001260496 NM_002906

HUGO

OMIM

CCDS

CCDS58171 CCDS58172 CCDS58173 CCDS58174 CCDS8343

HPRD

01534

IMGT

EMBL

GenPept

RNA Seq Atlas