InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TIMP2

Summary

InnateDB Gene

IDBG-70963.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMP2

Gene Name

TIMP metallopeptidase inhibitor 2

Synonyms

CSC-21K; DDC8

Species

Homo sapiens

Ensembl Gene

ENSG00000035862

Encoded Proteins

IDBP-70965

TIMP metallopeptidase inhibitor 2

IDBP-603287

TIMP metallopeptidase inhibitor 2

IDBP-760413

IDBP-759633

IDBP-763588

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:78852977-78925387

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000262768	ENSP00000262768
ENST00000536189	ENSP00000441724
ENST00000592761	ENSP00000464930
ENST00000586057	ENSP00000468296
ENST00000585421	ENSP00000467584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0007417	central nervous system development
GO:0007568	aging
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030814	regulation of cAMP metabolic process
GO:0032487	regulation of Rap protein signal transduction
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043408	regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045861	negative regulation of proteolysis
GO:0045930	negative regulation of mitotic cell cycle
GO:0046580	negative regulation of Ras protein signal transduction
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017466

View Gene Order

ENSBTAG00000010899

Not yet available

Pathways

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.633514

RefSeq

NM_003255

HUGO

OMIM

CCDS

CCDS11758

HPRD

01784

IMGT

EMBL

GenPept

RNA Seq Atlas