Homo sapiens Gene: TIMP2
Summary
InnateDB Gene IDBG-70963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMP2
Gene Name TIMP metallopeptidase inhibitor 2
Synonyms CSC-21K; DDC8;
Species Homo sapiens
Ensembl Gene ENSG00000035862
Encoded Proteins
TIMP metallopeptidase inhibitor 2
TIMP metallopeptidase inhibitor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:78852977-78925387
Strand Reverse strand
Band q25.3
Transcripts
ENST00000262768 ENSP00000262768
ENST00000536189 ENSP00000441724
ENST00000592761 ENSP00000464930
ENST00000586057 ENSP00000468296
ENST00000585421 ENSP00000467584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008191 metalloendopeptidase inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0007417 central nervous system development
GO:0007568 aging
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0010951 negative regulation of endopeptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030814 regulation of cAMP metabolic process
GO:0032487 regulation of Rap protein signal transduction
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0043408 regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0045664 regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045861 negative regulation of proteolysis
GO:0045930 negative regulation of mitotic cell cycle
GO:0046580 negative regulation of Ras protein signal transduction
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0030426 growth cone
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
KEGG
INOH
PID BIOCARTA
Inhibition of matrix metalloproteinases [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL B4DFW2 K7EL90
UniProt Splice Variant
Entrez Gene 7077
UniGene Hs.633514
RefSeq NM_003255
HUGO HGNC:11821
OMIM 188825
CCDS CCDS11758
HPRD 01784
IMGT
EMBL AC022966 AC100788 AK294290 CH471099
GenPept BAG57573 EAW89541
RNA Seq Atlas 7077