Homo sapiens Gene: PAK2
Summary
InnateDB Gene IDBG-71333.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK2
Gene Name p21 protein (Cdc42/Rac)-activated kinase 2
Synonyms PAK65; PAKgamma;
Species Homo sapiens
Ensembl Gene ENSG00000180370
Encoded Proteins
p21 protein (Cdc42/Rac)-activated kinase 2
p21 protein (Cdc42/Rac)-activated kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196739857-196832647
Strand Forward strand
Band q29
Transcripts
ENST00000327134 ENSP00000314067
ENST00000426668 ENSP00000402927
ENST00000481344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 92 [view]
Protein-Protein 91 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0030296 protein tyrosine kinase activator activity
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0040008 regulation of growth
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0050690 regulation of defense response to virus by virus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Stimulation of the cell death response by PAK-2p34 pathway
Apoptotic execution phase pathway
Developmental Biology pathway
Nef and signal transduction pathway
TCR signaling pathway
Semaphorin interactions pathway
Signaling by VEGF pathway
Innate Immune System pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
VEGFR2 mediated vascular permeability pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Activation of Rac pathway
Apoptosis pathway
Signal Transduction pathway
CD28 co-stimulation pathway
CD28 dependent Vav1 pathway pathway
Sema3A PAK dependent Axon repulsion pathway
Adaptive Immune System pathway
Immune System pathway
Ephrin signaling pathway
VEGFA-VEGFR2 Pathway pathway
HIV Infection pathway
EPH-Ephrin signaling pathway
Signaling by Robo receptor pathway
Regulation of PAK-2p34 activity by PS-GAP/RHG10 pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
Host Interactions of HIV factors pathway
Regulation of Apoptosis pathway
Disease pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Renal cell carcinoma pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
Fas signaling pathway (cd95) [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
RAC1 signaling pathway
C-MYC pathway
Signaling events mediated by VEGFR1 and VEGFR2
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt Q13177
TrEMBL H9XFB4
UniProt Splice Variant
Entrez Gene 5062
UniGene Hs.518530 Hs.613790 Hs.618519 Hs.620793
RefSeq NM_002577
HUGO HGNC:8591
OMIM 605022
CCDS CCDS3321
HPRD 05428
IMGT
EMBL BC069613 JQ511946 U24153 U25975
GenPept AAA65442 AAA75468 AAH69613 AFG72980
RNA Seq Atlas 5062