Version 5.4
Homo sapiens Gene: NCAM1
Summary
InnateDB Gene IDBG-71584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCAM1
Gene Name neural cell adhesion molecule 1
Synonyms CD56; MSK39; NCAM
Species Homo sapiens
Ensembl Gene ENSG00000149294
Encoded Proteins
IDBP-71586
neural cell adhesion molecule 1
IDBP-293815
neural cell adhesion molecule 1
IDBP-809629
neural cell adhesion molecule 1
IDBP-809631
neural cell adhesion molecule 1
IDBP-809655
neural cell adhesion molecule 1
IDBP-809657
neural cell adhesion molecule 1
IDBP-809658
neural cell adhesion molecule 1
IDBP-809660
neural cell adhesion molecule 1
IDBP-809662
neural cell adhesion molecule 1
IDBP-809615
neural cell adhesion molecule 1
IDBP-809618
neural cell adhesion molecule 1
IDBP-809619
neural cell adhesion molecule 1
IDBP-809627
neural cell adhesion molecule 1
IDBP-809637
neural cell adhesion molecule 1
IDBP-809675
neural cell adhesion molecule 1
IDBP-809678
neural cell adhesion molecule 1
IDBP-809679
neural cell adhesion molecule 1
IDBP-809681
neural cell adhesion molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:112961247-113278436
Strand Forward strand
Band q23.2
Transcripts
ENST00000316851 ENSP00000318472
ENST00000401611 ENSP00000384055
ENST00000525973
ENST00000531044 ENSP00000484943
ENST00000529356 ENSP00000482205
ENST00000534046
ENST00000530543 ENSP00000484481
ENST00000526322 ENSP00000479687
ENST00000531817 ENSP00000475074
ENST00000533073
ENST00000528590 ENSP00000480269
ENST00000525355
ENST00000525691
ENST00000534516
ENST00000524916 ENSP00000478072
ENST00000530090
ENST00000531927
ENST00000533226
ENST00000528158
ENST00000619839 ENSP00000480132
ENST00000621128 ENSP00000481083
ENST00000613217 ENSP00000479353
ENST00000617166
ENST00000620046 ENSP00000482852
ENST00000615525
ENST00000621850 ENSP00000480774
ENST00000611284
ENST00000618266 ENSP00000477835
ENST00000615112 ENSP00000480797
ENST00000615285 ENSP00000479241
ENST00000621518 ENSP00000477808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001928 regulation of exocyst assembly
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007411 axon guidance
GO:0019221 cytokine-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0031175 neuron projection development
GO:0034109 homotypic cell-cell adhesion
GO:0050850 positive regulation of calcium-mediated signaling
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0031225 anchored component of membrane
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039542
View Gene Order
ENSBTAG00000005710
Not yet available
Pathways
NETPATH
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_18266
Axon guidance pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05020
Prion diseases pathway
INOH
PID NCI
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4684
UniGene
RefSeq NM_001242607 NM_000615 NM_001076682 NM_001242608 NM_181351
HUGO HGNC:7656
OMIM 116930
CCDS CCDS73384 CCDS73385 CCDS73386 CCDS73387 CCDS73388
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 4684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca