InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIAA0226

Summary

InnateDB Gene

IDBG-71731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIAA0226

Gene Name

KIAA0226

Synonyms

RUBICON; SCAR15

Species

Homo sapiens

Ensembl Gene

ENSG00000145016

Encoded Proteins

IDBP-71733

KIAA0226

IDBP-71737

KIAA0226

IDBP-387255

KIAA0226

IDBP-387256

KIAA0226

IDBP-387257

KIAA0226

IDBP-387258

KIAA0226

IDBP-812567

KIAA0226

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22423967

RUBICON is a physiological feedback inhibitor of pattern recognition receptor signalling, preventing unbalanced proinflammatory responses.

PMID 22423966

RUBICON positively regulates the NADPH oxidase complex to induce phagosomal trafficking of p22phox-gp91phox (which are subunits of NADPH oxidase), and the induction of reactive oxygen species and inflammatory cytokines.

InnateDB Annotation from Orthologs

Summary

PMID 22423967

[Mus musculus] Rubicon is a physiological feedback inhibitor of pattern recognition receptor signalling, preventing unbalanced proinflammatory responses. (Demonstrated in human)

PMID 22423966

[Mus musculus] Rubicon positively regulates the NADPH oxidase complex to induce phagosomal trafficking of p22phox-gp91phox (which are subunits of NADPH oxidase), and the induction of reactive oxygen species and inflammatory cytokines. (Demonstrated in human)

Entrez Gene

Summary

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:197671393-197749727

Strand

Reverse strand

Band

q29

Transcripts

ENST00000273582	ENSP00000273582
ENST00000296343	ENSP00000296343
ENST00000413360	ENSP00000405115
ENST00000415452	ENSP00000409618
ENST00000447048	ENSP00000411894
ENST00000449205	ENSP00000390962
ENST00000471364
ENST00000467303
ENST00000474214	ENSP00000485041
ENST00000472149

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0006914	autophagy
GO:0010507	negative regulation of autophagy
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035629

View Gene Order

ENSBTAG00000001890

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.478868 Hs.602423 Hs.660308

RefSeq

NM_001145642 NM_014687 XM_005269374

HUGO

OMIM

CCDS

CCDS43195 CCDS46987

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas