|Homo sapiens Gene: KIAA0226|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Useful resources||Stemformatics EHFPI ImmGen|
RUBICON is a physiological feedback inhibitor of pattern recognition receptor signalling, preventing unbalanced proinflammatory responses.
RUBICON positively regulates the NADPH oxidase complex to induce phagosomal trafficking of p22phox-gp91phox (which are subunits of NADPH oxidase), and the induction of reactive oxygen species and inflammatory cytokines.
|InnateDB Annotation from Orthologs|
[Mus musculus] Rubicon is a physiological feedback inhibitor of pattern recognition receptor signalling, preventing unbalanced proinflammatory responses. (Demonstrated in human)
[Mus musculus] Rubicon positively regulates the NADPH oxidase complex to induce phagosomal trafficking of p22phox-gp91phox (which are subunits of NADPH oxidase), and the induction of reactive oxygen species and inflammatory cytokines. (Demonstrated in human)
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
|Genomic Location||Chromosome 3:197671393-197749727|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Not yet available
|UniProt Splice Variant|
|UniGene||Hs.478868 Hs.602423 Hs.660308|
|RefSeq||NM_001145642 NM_014687 XM_005269374|
|RNA Seq Atlas|