Version 5.4
Homo sapiens Gene: APEX2
Summary
InnateDB Gene IDBG-72022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APEX2
Gene Name APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169188
Encoded Proteins
IDBP-72024
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:55000357-55009057
Strand Forward strand
Band p11.21
Transcripts
ENST00000374987 ENSP00000364126
ENST00000471758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 nuclease activity
GO:0008270 zinc ion binding
GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006310 DNA recombination
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025269
View Gene Order
ENSBTAG00000013177
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.555936 Hs.659558
RefSeq NM_014481
HUGO
OMIM
CCDS CCDS14365
HPRD 06442
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca