Homo sapiens Gene: POLR2F
Summary
InnateDB Gene IDBG-7203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2F
Gene Name polymerase (RNA) II (DNA directed) polypeptide F
Synonyms HRBP14.4; POLRF; RPABC14.4; RPABC2; RPB14.4; RPB6; RPC15;
Species Homo sapiens
Ensembl Gene ENSG00000100142
Encoded Proteins
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
polymerase (RNA) II (DNA directed) polypeptide F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
During the transcriptional response to Sendai virus infection, POLR2F(RNA Pol II) is recruited by IRF3 and NFκB to control virus induced gene activation.
Entrez Gene
Summary This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. [provided by RefSeq, Jul 2008]
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37952607-38041915
Strand Forward strand
Band q13.1
Transcripts
ENST00000333418 ENSP00000332130
ENST00000407936 ENSP00000385725
ENST00000405557 ENSP00000384112
ENST00000442738 ENSP00000403852
ENST00000443002 ENSP00000406826
ENST00000427034 ENSP00000389307
ENST00000484894
ENST00000460648 ENSP00000475257
ENST00000488684 ENSP00000475342
ENST00000483713 ENSP00000476132
ENST00000492213 ENSP00000475343
ENST00000470701 ENSP00000475707
ENST00000606538 ENSP00000476187
ENST00000608713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 162 [view]
Protein-Protein 20 [view]
Protein-DNA 142 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001055 RNA polymerase II activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response (InnateDB)
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation pathway
Formation of the Early Elongation Complex pathway
Transcription-coupled NER (TC-NER) pathway
Influenza Infection pathway
RNA Polymerase I Transcription pathway
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
MicroRNA (miRNA) biogenesis pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase III Transcription Termination pathway
Innate Immune System pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Late Phase of HIV Life Cycle pathway
mRNA Splicing - Minor Pathway pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Epigenetic regulation of gene expression pathway
Influenza Viral RNA Transcription and Replication pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
RNA Polymerase I Transcription Termination pathway
Tat-mediated elongation of the HIV-1 transcript pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
Tat-mediated HIV elongation arrest and recovery pathway
RNA Polymerase III Chain Elongation pathway
Formation of RNA Pol II elongation complex pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
RNA Polymerase II Transcription pathway
Immune System pathway
RNA Polymerase II HIV Promoter Escape pathway
Dual incision reaction in TC-NER pathway
Pausing and recovery of HIV elongation pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
HIV elongation arrest and recovery pathway
RNA Polymerase III Transcription pathway
RNA Polymerase II Pre-transcription Events pathway
mRNA Capping pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
Transcription of the HIV genome pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Influenza Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
mRNA Splicing pathway
HIV Transcription Initiation pathway
Formation of the HIV-1 Early Elongation Complex pathway
Cytosolic sensors of pathogen-associated DNA pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
mRNA Splicing - Major Pathway pathway
Regulatory RNA pathways pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA polymerase pathway
Cytosolic DNA-sensing pathway pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.735742
RefSeq NM_001301130 NM_021974
HUGO
OMIM
CCDS CCDS13963
HPRD 05105
IMGT
EMBL
GenPept
RNA Seq Atlas