Homo sapiens Gene: EPB41L1
Summary
InnateDB Gene IDBG-72099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPB41L1
Gene Name erythrocyte membrane protein band 4.1-like 1
Synonyms 4.1N; MRD11;
Species Homo sapiens
Ensembl Gene ENSG00000088367
Encoded Proteins
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
erythrocyte membrane protein band 4.1-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The protein encoded by this gene is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:36091504-36232799
Strand Forward strand
Band q11.23
Transcripts
ENST00000202028 ENSP00000202028
ENST00000373950 ENSP00000363061
ENST00000373946 ENSP00000363057
ENST00000338074 ENSP00000337168
ENST00000373945 ENSP00000363056
ENST00000373941 ENSP00000363052
ENST00000406771 ENSP00000385244
ENST00000432589 ENSP00000393106
ENST00000430276 ENSP00000404341
ENST00000452261 ENSP00000413262
ENST00000447825 ENSP00000396366
ENST00000441639 ENSP00000399214
ENST00000427533 ENSP00000408877
ENST00000451082 ENSP00000406464
ENST00000454226 ENSP00000388281
ENST00000432603 ENSP00000390262
ENST00000479336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0007268 synaptic transmission
GO:0030866 cortical actin cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Trafficking of AMPA receptors pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Cross-References
SwissProt
TrEMBL Q4VXN0 Q4VXN1 Q4VXN2
UniProt Splice Variant
Entrez Gene 2036
UniGene Hs.437422 Hs.695199
RefSeq NM_001258331 NM_012156 NM_001258330 NM_177996 NM_001258329 XM_006723741 XM_006723739 XM_006723736 XM_006723738 XM_006723737 XM_005260323 XM_005260319
HUGO HGNC:3378
OMIM 602879
CCDS CCDS13272 CCDS13271 CCDS58771
HPRD 04193
IMGT
EMBL AL035420 AL121895
GenPept
RNA Seq Atlas 2036