InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HGS

Summary

InnateDB Gene

IDBG-72504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HGS

Gene Name

hepatocyte growth factor-regulated tyrosine kinase substrate

Synonyms

HRS

Species

Homo sapiens

Ensembl Gene

ENSG00000185359

Encoded Proteins

IDBP-72506

hepatocyte growth factor-regulated tyrosine kinase substrate

IDBP-759239

IDBP-759961

IDBP-764736

IDBP-763849

IDBP-762690

IDBP-758104

IDBP-762893

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81683326-81703138

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000329138	ENSP00000331201
ENST00000571885
ENST00000573320	ENSP00000458789
ENST00000571518	ENSP00000459685
ENST00000573949
ENST00000576087
ENST00000576393
ENST00000570652	ENSP00000460165
ENST00000575078	ENSP00000460130
ENST00000573080
ENST00000575058
ENST00000570355
ENST00000571237	ENSP00000458775
ENST00000577012	ENSP00000458603
ENST00000571647
ENST00000576498
ENST00000572392	ENSP00000458987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	203 [view]
Protein-Protein	203 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0008333	endosome to lysosome transport
GO:0016197	endosomal transport
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042176	regulation of protein catabolic process
GO:0046426	negative regulation of JAK-STAT cascade
GO:0061024	membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030141	secretory granule
GO:0031901	early endosome membrane
GO:0032585	multivesicular body membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome