Homo sapiens Gene: HGS
Summary
InnateDB Gene IDBG-72504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HGS
Gene Name hepatocyte growth factor-regulated tyrosine kinase substrate
Synonyms HRS;
Species Homo sapiens
Ensembl Gene ENSG00000185359
Encoded Proteins
hepatocyte growth factor-regulated tyrosine kinase substrate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81683326-81703138
Strand Forward strand
Band q25.3
Transcripts
ENST00000329138 ENSP00000331201
ENST00000571885
ENST00000573320 ENSP00000458789
ENST00000571518 ENSP00000459685
ENST00000573949
ENST00000576087
ENST00000576393
ENST00000570652 ENSP00000460165
ENST00000575078 ENSP00000460130
ENST00000573080
ENST00000575058
ENST00000570355
ENST00000571237 ENSP00000458775
ENST00000577012 ENSP00000458603
ENST00000571647
ENST00000576498
ENST00000572392 ENSP00000458987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 203 [view]
Protein-Protein 203 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0008333 endosome to lysosome transport
GO:0016197 endosomal transport
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042176 regulation of protein catabolic process
GO:0046426 negative regulation of JAK-STAT cascade
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0030141 secretory granule
GO:0031901 early endosome membrane
GO:0032585 multivesicular body membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
TCR pathway
REACTOME
Signaling by EGFR in Cancer pathway
Signaling by EGFR pathway
Signal Transduction pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
EGFR downregulation pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CXCR4-mediated signaling events
Internalization of ErbB1
Signaling events mediated by VEGFR1 and VEGFR2
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514590 Hs.661056 Hs.728531
RefSeq NM_004712 XM_005257794
HUGO
OMIM
CCDS CCDS11784
HPRD 05085
IMGT
EMBL
GenPept
RNA Seq Atlas