Homo sapiens Gene: UBQLN2
Summary
InnateDB Gene IDBG-72599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBQLN2
Gene Name ubiquilin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188021
Encoded Proteins
ubiquilin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:56563639-56567868
Strand Forward strand
Band p11.21
Transcripts
ENST00000338222 ENSP00000345195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 72 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006289 nucleotide-excision repair
GO:0008219 cell death
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.179309 Hs.522668
RefSeq NM_013444
HUGO
OMIM
CCDS CCDS14374
HPRD 02224
IMGT
EMBL
GenPept
RNA Seq Atlas