Homo sapiens Gene: RGS11
Summary
InnateDB Gene IDBG-7261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS11
Gene Name regulator of G-protein signaling 11
Synonyms RS11;
Species Homo sapiens
Ensembl Gene ENSG00000076344
Encoded Proteins
regulator of G-protein signaling 11
regulator of G-protein signaling 11
regulator of G-protein signaling 11
regulator of G-protein signaling 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:268301-275980
Strand Reverse strand
Band p13.3
Transcripts
ENST00000168869 ENSP00000168869
ENST00000316163 ENSP00000319069
ENST00000359740 ENSP00000352778
ENST00000397770 ENSP00000380876
ENST00000477143
ENST00000481672
ENST00000493449
ENST00000472466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0043234 protein complex
GO:0044292 dendrite terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O94810
TrEMBL H7C5Z0 Q4TT70
UniProt Splice Variant
Entrez Gene 8786
UniGene Hs.65756
RefSeq NM_001286485 NM_001286486 NM_003834 NM_183337
HUGO HGNC:9993
OMIM 603895
CCDS CCDS10403 CCDS42088 CCDS66884
HPRD
IMGT
EMBL AB016929 AC004754 AE006463 AF035153 AF035154 BC141803 CH471112 Z69667
GenPept AAC69175 AAC69176 AAI41804 AAK61221 BAA74751 CAI95581 CAI95582 CAI95583 EAW85839 EAW85843
RNA Seq Atlas 8786