Homo sapiens Gene: P4HB | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-72655.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | P4HB | ||||||||||||||||||||||
Gene Name | prolyl 4-hydroxylase, beta polypeptide | ||||||||||||||||||||||
Synonyms | DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000185624 | ||||||||||||||||||||||
Encoded Proteins |
prolyl 4-hydroxylase, beta polypeptide
prolyl 4-hydroxylase, beta polypeptide
prolyl 4-hydroxylase, beta polypeptide
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 17:81843159-81860694 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q25.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Collagen biosynthesis and modifying enzymes pathway
Chylomicron-mediated lipid transport pathway
Cellular responses to stress pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Metabolism of lipids and lipoproteins pathway
Extracellular matrix organization pathway
Detoxification of Reactive Oxygen Species pathway
Signal Transduction pathway
Hedgehog ligand biogenesis pathway
Lipoprotein metabolism pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Collagen formation pathway
Disease pathway
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KEGG |
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | I3L1Y5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 5034 | ||||||||||||||||||||||
UniGene | Hs.464336 | ||||||||||||||||||||||
RefSeq | NM_000918 | ||||||||||||||||||||||
HUGO | HGNC:8548 | ||||||||||||||||||||||
OMIM | 176790 | ||||||||||||||||||||||
CCDS | CCDS11787 | ||||||||||||||||||||||
HPRD | 07181 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC145207 AC174470 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 5034 | ||||||||||||||||||||||