Homo sapiens Gene: TRIM28
Summary
InnateDB Gene IDBG-73191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM28
Gene Name tripartite motif containing 28
Synonyms KAP1; PPP1R157; RNF96; TF1B; TIF1B;
Species Homo sapiens
Ensembl Gene ENSG00000130726
Encoded Proteins
tripartite motif containing 28
tripartite motif containing 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRIM28 interacts with IRF5 and mediates heterochromatinization at M1 macrophage markers (e.g. TNF) to suppress transcription.
Entrez Gene
Summary The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:58544091-58550722
Strand Forward strand
Band q13.43
Transcripts
ENST00000253024 ENSP00000253024
ENST00000341753 ENSP00000342232
ENST00000597423
ENST00000598355
ENST00000597995
ENST00000595028
ENST00000595974
ENST00000597618
ENST00000593582 ENSP00000472586
ENST00000601150
ENST00000597968 ENSP00000470503
ENST00000600840
ENST00000594806 ENSP00000473126
ENST00000597172
ENST00000597136 ENSP00000471303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 271 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 271 [view]
Protein-Protein 271 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0035851 Krueppel-associated box domain binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0070087 chromo shadow domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001837 epithelial to mesenchymal transition
GO:0006281 DNA repair
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0010467 gene expression
GO:0016567 protein ubiquitination
GO:0016925 protein sumoylation
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045087 innate immune response (InnateDB)
GO:0045739 positive regulation of DNA repair
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0051259 protein oligomerization
GO:0060028 convergent extension involved in axis elongation
GO:0060669 embryonic placenta morphogenesis
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0000785 chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005719 nuclear euchromatin
GO:0005720 nuclear heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Generic Transcription Pathway pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
p53 pathway
C-MYB transcription factor network
E2F transcription factor network
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467408
RefSeq NM_005762
HUGO
OMIM
CCDS CCDS12985
HPRD 03445
IMGT
EMBL
GenPept
RNA Seq Atlas