Version 5.4
Homo sapiens Gene: ITGB6
Summary
InnateDB Gene IDBG-73389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB6
Gene Name integrin, beta 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115221
Encoded Proteins
IDBP-73391
integrin, beta 6
IDBP-293903
integrin, beta 6
IDBP-293901
integrin, beta 6
IDBP-293902
integrin, beta 6
IDBP-386883
integrin, beta 6
IDBP-809959
integrin, beta 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:160099666-160271888
Strand Reverse strand
Band q24.2
Transcripts
ENST00000283249 ENSP00000283249
ENST00000409872 ENSP00000386367
ENST00000409583 ENSP00000386477
ENST00000409967 ENSP00000386828
ENST00000428609 ENSP00000408024
ENST00000475438
ENST00000485635
ENST00000498478
ENST00000459712
ENST00000477514
ENST00000620391 ENSP00000481183
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0005178 integrin binding
Biological Process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0009615 response to virus
GO:0016032 viral process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026971
View Gene Order
ENSBTAG00000009080
Not yet available
Pathways
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin_cs_pathway
Integrin family cell surface interactions
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470399 Hs.622941
RefSeq NM_000888 NM_001282353 NM_001282354 NM_001282355 NM_001282388 NM_001282389 NM_001282390
HUGO
OMIM
CCDS CCDS2212 CCDS63040 CCDS74596 CCDS74597
HPRD 00947
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca