Version 5.4
Homo sapiens Gene: IL10RA
Summary
InnateDB Gene IDBG-73419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL10RA
Gene Name interleukin 10 receptor, alpha
Synonyms CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
Species Homo sapiens
Ensembl Gene ENSG00000110324
Encoded Proteins
IDBP-73421
interleukin 10 receptor, alpha
IDBP-601892
interleukin 10 receptor, alpha
IDBP-589902
interleukin 10 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117986348-118001483
Strand Forward strand
Band q23.3
Transcripts
ENST00000227752 ENSP00000227752
ENST00000530761
ENST00000533700
ENST00000526544 ENSP00000435317
ENST00000534574 ENSP00000436328
ENST00000531365
ENST00000529924
ENST00000534335
ENST00000530178
ENST00000532009
ENST00000525467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004872 receptor activity
GO:0004920 interleukin-10 receptor activity
GO:0005515 protein binding
GO:0019969 interleukin-10 binding
Biological Process
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032089
View Gene Order
ENSBTAG00000005215
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-10 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.504035 Hs.599715
RefSeq NM_001558 XM_006718833
HUGO
OMIM
CCDS CCDS8388
HPRD 00911
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca