Homo sapiens Gene: CHMP2A
Summary
InnateDB Gene IDBG-73495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP2A
Gene Name charged multivesicular body protein 2A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130724
Encoded Proteins
charged multivesicular body protein 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:58551566-58555124
Strand Reverse strand
Band q13.43
Transcripts
ENST00000312547 ENSP00000310440
ENST00000600804
ENST00000600118 ENSP00000469240
ENST00000601220 ENSP00000472680
ENST00000596708 ENSP00000471961
ENST00000597209
ENST00000600006 ENSP00000472097
ENST00000597848 ENSP00000469453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007034 vacuolar transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0045184 establishment of protein localization
GO:0050792 regulation of viral process
GO:0061024 membrane organization
GO:1902188 positive regulation of viral release from host cell
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Budding and maturation of HIV virion pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43633
TrEMBL A0A024R4S0 M0QXX8 M0R1L7
UniProt Splice Variant
Entrez Gene 27243
UniGene
RefSeq NM_014453 NM_198426 XM_005258746 XM_005258747
HUGO HGNC:30216
OMIM 610893
CCDS CCDS12986
HPRD 12520
IMGT
EMBL AC016630 AF042384 AJ277113 AK311974 AY364248 BC002502 BT007298 CH471135 CR457002
GenPept AAC00005 AAH02502 AAP35962 AAQ76807 BAG34913 CAC14310 CAG33283 EAW72609 EAW72610 EAW72611
RNA Seq Atlas 27243