InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX6

Summary

InnateDB Gene

IDBG-74041.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX6

Gene Name

DEAD (Asp-Glu-Ala-Asp) box helicase 6

Synonyms

HLR2; P54; RCK

Species

Homo sapiens

Ensembl Gene

ENSG00000110367

Encoded Proteins

IDBP-586250

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

IDBP-592245

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

IDBP-808410

DEAD (Asp-Glu-Ala-Asp) box helicase 6

IDBP-808411

DEAD (Asp-Glu-Ala-Asp) box helicase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118747766-118791149

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000529162
ENST00000526070	ENSP00000433704
ENST00000525082
ENST00000531971
ENST00000533239
ENST00000534980	ENSP00000442266
ENST00000620157	ENSP00000478754
ENST00000617381	ENSP00000483902

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006200	ATP catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0016442	RISC complex
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032097

View Gene Order

ENSBTAG00000009067

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_20518

mRNA decay by 5' to 3' exoribonuclease pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001257191 NM_004397 XM_005271417

HUGO

OMIM

CCDS

CCDS44751

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas