Homo sapiens Gene: SRC
Summary
InnateDB Gene IDBG-74081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRC
Gene Name v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Synonyms ASV; c-SRC; p60-Src; SRC1;
Species Homo sapiens
Ensembl Gene ENSG00000197122
Encoded Proteins
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SRC and STAT3 play a role in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.
Entrez Gene
Summary This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:37344685-37406050
Strand Forward strand
Band q11.23
Transcripts
ENST00000373578 ENSP00000362680
ENST00000358208 ENSP00000350941
ENST00000373567 ENSP00000362668
ENST00000373558 ENSP00000362659
ENST00000497734
ENST00000472968
ENST00000489153
ENST00000477066
ENST00000467556
ENST00000477475
ENST00000493775
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 446 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 446 [view]
Protein-Protein 443 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005080 protein kinase C binding
GO:0005102 receptor binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0020037 heme binding
GO:0030331 estrogen receptor binding
GO:0032403 protein complex binding
GO:0042169 SH2 domain binding
GO:0044325 ion channel binding
GO:0046875 ephrin receptor binding
GO:0050839 cell adhesion molecule binding
GO:0051219 phosphoprotein binding
GO:0070851 growth factor receptor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0010447 response to acidity
GO:0010628 positive regulation of gene expression
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0010907 positive regulation of glucose metabolic process
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016032 viral process
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030168 platelet activation
GO:0030900 forebrain development
GO:0031295 T cell costimulation
GO:0031667 response to nutrient levels
GO:0031954 positive regulation of protein autophosphorylation
GO:0032148 activation of protein kinase B activity
GO:0032463 negative regulation of protein homooligomerization
GO:0032869 cellular response to insulin stimulus
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0033625 positive regulation of integrin activation
GO:0034332 adherens junction organization
GO:0035556 intracellular signal transduction
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 regulation of protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045056 transcytosis
GO:0045087 innate immune response (InnateDB)
GO:0045124 regulation of bone resorption
GO:0045453 bone resorption
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048477 oogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0050847 progesterone receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051222 positive regulation of protein transport
GO:0051385 response to mineralocorticoid
GO:0051602 response to electrical stimulus
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051902 negative regulation of mitochondrial depolarization
GO:0060065 uterus development
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0061024 membrane organization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070542 response to fatty acid
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071393 cellular response to progesterone stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071803 positive regulation of podosome assembly
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902533 positive regulation of intracellular signal transduction
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000811 negative regulation of anoikis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0014069 postsynaptic density
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
TCR pathway
IL3 pathway
RANKL pathway
Leptin pathway
TSH pathway
TSLP pathway
FSH pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
Signal Transduction pathway
Signaling by ERBB2 pathway
KEGG
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Endocytosis pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Gap junction pathway
Regulation of actin cytoskeleton pathway
GnRH signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
INOH
GPCR signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Biocarta view]
Pelp1 modulation of estrogen receptor activity [Biocarta view]
Ucalpain and friends in cell spread [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Gamma-aminobutyric acid receptor life cycle pathway [Biocarta view]
Cell to cell adhesion signaling [Biocarta view]
Integrin signaling pathway [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Regulation of splicing through sam68 [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Syndecan-2-mediated signaling events
Nongenotropic Androgen signaling
Atypical NF-kappaB pathway
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events
LPA receptor mediated events
Class I PI3K signaling events mediated by Akt
Integrins in angiogenesis
Internalization of ErbB1
Signaling events mediated by PTP1B
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ErbB1 downstream signaling
Alpha9 beta1 integrin signaling events
Nectin adhesion pathway
Signaling events mediated by focal adhesion kinase
EPHB forward signaling
Syndecan-3-mediated signaling events
FGF signaling pathway
Endothelins
Signaling events mediated by TCPTP
Signaling events mediated by PRL
ErbB2/ErbB3 signaling events
S1P3 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
CXCR3-mediated signaling events
Regulation of Androgen receptor activity
EPHA2 forward signaling
E-cadherin signaling in keratinocytes
Arf6 signaling events
Posttranslational regulation of adherens junction stability and dissassembly
FAS (CD95) signaling pathway
Cross-References
SwissProt P12931
TrEMBL Q71UK5 Q9H7V3
UniProt Splice Variant
Entrez Gene 6714
UniGene Hs.195659 Hs.597733 Hs.675407
RefSeq NM_005417 NM_198291
HUGO HGNC:11283
OMIM 190090
CCDS CCDS13294
HPRD 01819
IMGT
EMBL AF077754 AK024281 AL133293 BC011566 BC051270 CH471077 K03212 K03213 K03214 K03215 K03216 K03217 K03218 M16237 M16243 M16244 M16245 X02647 X03995 X03996 X03997 X03998 X03999 X04000
GenPept AAA60584 AAC29427 AAH11566 AAH51270 BAB14871 CAA26485 CAC10573 CAC34523 EAW76064 EAW76065 EAW76066 EAW76067
RNA Seq Atlas 6714