Homo sapiens Gene: GATA4
Summary
InnateDB Gene IDBG-7434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATA4
Gene Name GATA binding protein 4
Synonyms ASD2; TACHD; TOF; VSD1;
Species Homo sapiens
Ensembl Gene ENSG00000136574
Encoded Proteins
GATA binding protein 4
GATA binding protein 4
GATA binding protein 4
GATA binding protein 4
GATA binding protein 4
GATA binding protein 4
GATA binding protein 4
GATA binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
GATA4 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG) proteins, ZFPM1 and ZFPM2, moderate this transcription by suppressing the GATA transactivation of hepcidin promoter.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Gata4 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11676959-11760002
Strand Forward strand
Band p23.1
Transcripts
ENST00000335135 ENSP00000334458
ENST00000528712 ENSP00000435043
ENST00000532977 ENSP00000473671
ENST00000526974 ENSP00000473598
ENST00000526716 ENSP00000435347
ENST00000528027 ENSP00000432278
ENST00000532059 ENSP00000435712
ENST00000526021
ENST00000622443 ENSP00000482268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0033613 activating transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0051525 NFAT protein binding
GO:0070410 co-SMAD binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001947 heart looping
GO:0003181 atrioventricular valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003208 cardiac ventricle morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003281 ventricular septum development
GO:0003289 atrial septum primum morphogenesis
GO:0003290 atrial septum secundum morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0035050 embryonic heart tube development
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035239 tube morphogenesis
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048557 embryonic digestive tract morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048617 embryonic foregut morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0051891 positive regulation of cardioblast differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0060008 Sertoli cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060290 transdifferentiation
GO:0060395 SMAD protein signal transduction
GO:0060413 atrial septum morphogenesis
GO:0060464 lung lobe formation
GO:0060575 intestinal epithelial cell differentiation
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0071333 cellular response to glucose stimulus
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072148 epithelial cell fate commitment
GO:0072520 seminiferous tubule development
GO:0086004 regulation of cardiac muscle cell contraction
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Incretin synthesis, secretion, and inactivation pathway
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
Generic Transcription Pathway pathway
Metabolism of proteins pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Factors involved in megakaryocyte development and platelet production pathway
Peptide hormone metabolism pathway
Gene Expression pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
Nfat and hypertrophy of the heart [Biocarta view]
Alk in cardiac myocytes [Biocarta view]
Hop pathway in cardiac development [Biocarta view]
PID NCI
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.243987 Hs.738813
RefSeq NM_002052 XM_005272384 XM_005272385 XM_005272386 XM_006716248 XM_006716249
HUGO
OMIM
CCDS CCDS5983
HPRD 08994
IMGT
EMBL
GenPept
RNA Seq Atlas