InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GATA4

Summary

InnateDB Gene

IDBG-7434.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GATA4

Gene Name

GATA binding protein 4

Synonyms

ASD2; TACHD; TOF; VSD1

Species

Homo sapiens

Ensembl Gene

ENSG00000136574

Encoded Proteins

IDBP-7438

GATA binding protein 4

IDBP-599765

GATA binding protein 4

IDBP-813144

GATA binding protein 4

IDBP-813145

GATA binding protein 4

IDBP-603585

GATA binding protein 4

IDBP-588037

GATA binding protein 4

IDBP-592775

GATA binding protein 4

IDBP-813148

GATA binding protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21971825

GATA4 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG) proteins, ZFPM1 and ZFPM2, moderate this transcription by suppressing the GATA transactivation of hepcidin promoter.

InnateDB Annotation from Orthologs

Summary

PMID 21971825

[Mus musculus] Gata4 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:11676959-11760002

Strand

Forward strand

Band

p23.1

Transcripts

ENST00000335135	ENSP00000334458
ENST00000528712	ENSP00000435043
ENST00000532977	ENSP00000473671
ENST00000526974	ENSP00000473598
ENST00000526716	ENSP00000435347
ENST00000528027	ENSP00000432278
ENST00000532059	ENSP00000435712
ENST00000526021
ENST00000622443	ENSP00000482268

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0033613	activating transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0051525	NFAT protein binding
GO:0070410	co-SMAD binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001706	endoderm formation
GO:0001947	heart looping
GO:0003181	atrioventricular valve morphogenesis
GO:0003197	endocardial cushion development
GO:0003208	cardiac ventricle morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003229	ventricular cardiac muscle tissue development
GO:0003281	ventricular septum development
GO:0003289	atrial septum primum morphogenesis
GO:0003290	atrial septum secundum morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007492	endoderm development
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0008584	male gonad development
GO:0009612	response to mechanical stimulus
GO:0010468	regulation of gene expression
GO:0010507	negative regulation of autophagy
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0035050	embryonic heart tube development
GO:0035054	embryonic heart tube anterior/posterior pattern specification
GO:0035239	tube morphogenesis
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048557	embryonic digestive tract morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0048738	cardiac muscle tissue development
GO:0051891	positive regulation of cardioblast differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0060008	Sertoli cell differentiation
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060070	canonical Wnt signaling pathway
GO:0060290	transdifferentiation
GO:0060395	SMAD protein signal transduction
GO:0060413	atrial septum morphogenesis
GO:0060464	lung lobe formation
GO:0060575	intestinal epithelial cell differentiation
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071333	cellular response to glucose stimulus
GO:0071371	cellular response to gonadotropin stimulus
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0072148	epithelial cell fate commitment
GO:0072520	seminiferous tubule development
GO:0086004	regulation of cardiac muscle cell contraction