Homo sapiens Gene: CBL
InnateDB Gene IDBG-74417.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBL
Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase
Synonyms C-CBL; CBL2; FRA11B; NSLL; RNF55;
Species Homo sapiens
Ensembl Gene ENSG00000110395
Encoded Proteins
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
CBL, an E3 ligase, has a crucial role in regulating dendritic cell maturation by facilitating the regulatory functions of NFKB1. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
[Mus musculus] Cbl, an E3 ligase, has a crucial role in regulating dendritic cell maturation by facilitating the regulatory functions of Nfkb1.
Entrez Gene
Summary This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119206042-119308149
Strand Forward strand
Band q23.3
ENST00000264033 ENSP00000264033
Number of Interactions This gene and/or its encoded proteins are associated with 365 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 365 [view]
Protein-Protein 364 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017124 SH3 domain binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016567 protein ubiquitination
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048260 positive regulation of receptor-mediated endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016600 flotillin complex
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Prolactin pathway
Signaling by FGFR in disease pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signaling by EGFR in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by constitutively active EGFR pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Signaling by SCF-KIT pathway
Spry regulation of FGF signaling pathway
Interleukin-6 signaling pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Signaling by Interleukins pathway
TGFBR1 KD Mutants in Cancer pathway
EGFR downregulation pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by FGFR pathway
TGFBR1 LBD Mutants in Cancer pathway
Regulation of KIT signaling pathway
Negative regulation of FGFR signaling pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Regulation of signaling by CBL pathway
ErbB signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
Insulin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Il-2 receptor beta chain in t cell activation [Biocarta view]
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
EPHA forward signaling
TCR signaling in na´ve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL8- and CXCR2-mediated signaling events
Reelin signaling pathway
IL8- and CXCR1-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Integrins in angiogenesis
Internalization of ErbB1
EPO signaling pathway
FGF signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
CDC42 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
PDGFR-beta signaling pathway
Insulin Pathway
IFN-gamma pathway
Notch signaling pathway
SwissProt P22681
UniProt Splice Variant
Entrez Gene 867
UniGene Hs.504096
RefSeq NM_005188
OMIM 165360
EMBL AP002956 BC132733 BC136463 X57110
GenPept AAI32734 AAI36464 CAA40393
RNA Seq Atlas 867