Homo sapiens Gene: CBL | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-74417.7 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | CBL | ||||||||||||||||||||||||
Gene Name | Cbl proto-oncogene, E3 ubiquitin protein ligase | ||||||||||||||||||||||||
Synonyms | C-CBL; CBL2; FRA11B; NSLL; RNF55 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000110395 | ||||||||||||||||||||||||
Encoded Proteins |
Cas-Br-M (murine) ecotropic retroviral transforming sequence
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||
Summary |
CBL, an E3 ligase, has a crucial role in regulating dendritic cell maturation by facilitating the regulatory functions of NFKB1. (Demonstrated in mouse)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Mus musculus] Cbl, an E3 ligase, has a crucial role in regulating dendritic cell maturation by facilitating the regulatory functions of Nfkb1.
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 11:119206042-119308149 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | q23.3 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 365 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Prolactin pathway
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REACTOME |
Interleukin-6 signaling pathway
Regulation of signaling by CBL pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
EGFR downregulation pathway
Signaling by EGFR pathway
TGF-beta receptor signaling activates SMADs pathway
Spry regulation of FGF signaling pathway
Negative regulation of FGFR signaling pathway
Signaling by FGFR pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Signaling by constitutively active EGFR pathway
Signaling by FGFR in disease pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signaling by EGFR in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Cytokine Signaling in Immune system pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by Interleukins pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
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KEGG |
ErbB signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Insulin signaling pathway pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Chronic myeloid leukemia pathway
Endocytosis pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
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INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR signaling pathway
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PID NCI |
EPHA forward signaling
TCR signaling in naïve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL8- and CXCR2-mediated signaling events
Reelin signaling pathway
IL8- and CXCR1-mediated signaling events
TCR signaling in naïve CD4+ T cells
Integrins in angiogenesis
Internalization of ErbB1
EPO signaling pathway
FGF signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
CDC42 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
PDGFR-beta signaling pathway
Insulin Pathway
IFN-gamma pathway
Notch signaling pathway
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Cross-References | |||||||||||||||||||||||||
SwissProt | P22681 | ||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 867 | ||||||||||||||||||||||||
UniGene | Hs.504096 | ||||||||||||||||||||||||
RefSeq | NM_005188 | ||||||||||||||||||||||||
HUGO | HGNC:1541 | ||||||||||||||||||||||||
OMIM | 165360 | ||||||||||||||||||||||||
CCDS | CCDS8418 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AP002956 BC132733 BC136463 X57110 | ||||||||||||||||||||||||
GenPept | AAI32734 AAI36464 CAA40393 | ||||||||||||||||||||||||
RNA Seq Atlas | 867 | ||||||||||||||||||||||||