Homo sapiens Gene: DKK1
Summary
InnateDB Gene IDBG-74684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DKK1
Gene Name dickkopf 1 homolog (Xenopus laevis)
Synonyms DKK-1; SK;
Species Homo sapiens
Ensembl Gene ENSG00000107984
Encoded Proteins
dickkopf homolog 1 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:52314296-52318042
Strand Forward strand
Band q21.1
Transcripts
ENST00000373970 ENSP00000363081
ENST00000467359
ENST00000494277
ENST00000476752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0048019 receptor antagonist activity
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000904 cell morphogenesis involved in differentiation
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001942 hair follicle development
GO:0002090 regulation of receptor internalization
GO:0007275 multicellular organismal development
GO:0007492 endoderm development
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0030514 negative regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0031333 negative regulation of protein complex assembly
GO:0032526 response to retinoic acid
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042663 regulation of endodermal cell fate specification
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0060323 head morphogenesis
GO:0060325 face morphogenesis
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:1900116 extracellular negative regulation of signal transduction
GO:1901296 negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:2000726 negative regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Segmentation clock [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Wnt lrp6 signalling [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Wnt signaling network
Direct p53 effectors
Validated targets of C-MYC transcriptional repression
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt O94907
TrEMBL I1W660
UniProt Splice Variant
Entrez Gene 22943
UniGene Hs.40499
RefSeq NM_012242
HUGO HGNC:2891
OMIM 605189
CCDS CCDS7246
HPRD 05544
IMGT
EMBL AB020315 AF127563 AF177394 AF261157 AF261158 AK314902 AY359005 BC001539 CH471083 JN966744
GenPept AAD21087 AAF02674 AAG15544 AAH01539 AAQ89364 AFI61647 BAA34651 BAG37416 EAW54144
RNA Seq Atlas 22943