InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HSPA8

Summary

InnateDB Gene

IDBG-74847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA8

Gene Name

heat shock 70kDa protein 8

Synonyms

HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71

Species

Homo sapiens

Ensembl Gene

ENSG00000109971

Encoded Proteins

IDBP-74849

heat shock 70kDa protein 8

IDBP-384205

heat shock 70kDa protein 8

IDBP-598462

heat shock 70kDa protein 8

IDBP-592645

heat shock 70kDa protein 8

IDBP-589172

heat shock 70kDa protein 8

IDBP-591257

heat shock 70kDa protein 8

IDBP-583636

heat shock 70kDa protein 8

IDBP-589131

heat shock 70kDa protein 8

IDBP-602209

heat shock 70kDa protein 8

IDBP-595325

heat shock 70kDa protein 8

IDBP-585848

heat shock 70kDa protein 8

IDBP-593320

heat shock 70kDa protein 8

IDBP-588762

heat shock 70kDa protein 8

IDBP-599895

heat shock 70kDa protein 8

IDBP-592104

heat shock 70kDa protein 8

IDBP-584065

heat shock 70kDa protein 8

IDBP-589968

heat shock 70kDa protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:123057489-123063230

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000227378	ENSP00000227378
ENST00000453788	ENSP00000404372
ENST00000532636	ENSP00000437125
ENST00000533540	ENSP00000437189
ENST00000534624	ENSP00000432083
ENST00000532091
ENST00000534319	ENSP00000433316
ENST00000526110	ENSP00000433584
ENST00000524552	ENSP00000435908
ENST00000526686	ENSP00000435019
ENST00000533238
ENST00000526862
ENST00000527983
ENST00000528292	ENSP00000432884
ENST00000532780
ENST00000525463	ENSP00000436762
ENST00000532167
ENST00000525624	ENSP00000435154
ENST00000534567	ENSP00000431641
ENST00000527387	ENSP00000436183
ENST00000532182	ENSP00000434415
ENST00000524590	ENSP00000434565
ENST00000530391	ENSP00000434851
ENST00000531063

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 371 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	371 [view]
Protein-Protein	367 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0023026	MHC class II protein complex binding
GO:0031072	heat shock protein binding
GO:0042623	ATPase activity, coupled
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006986	response to unfolded protein
GO:0007049	cell cycle
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007411	axon guidance
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0042026	protein refolding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051726	regulation of cell cycle
GO:0061024	membrane organization
GO:0072318	clathrin coat disassembly
GO:1902904	negative regulation of fibril organization

Cellular Component

GO:0000974	Prp19 complex
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0042470	melanosome
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle