Homo sapiens Gene: IL2RG
Summary
InnateDB Gene IDBG-74884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2RG
Gene Name interleukin 2 receptor, gamma
Synonyms CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1;
Species Homo sapiens
Ensembl Gene ENSG00000147168
Encoded Proteins
interleukin 2 receptor, gamma
interleukin 2 receptor, gamma
interleukin 2 receptor, gamma
interleukin 2 receptor, gamma
interleukin 2 receptor, gamma
interleukin 2 receptor, gamma
interleukin 2 receptor, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL2RG physically associates with JAK2, suggesting that regulation of JAK2 may be linked to IL2 induced signal transduction.
Entrez Gene
Summary The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:71107404-71112108
Strand Reverse strand
Band q13.1
Transcripts
ENST00000374202 ENSP00000363318
ENST00000276110
ENST00000374188 ENSP00000363303
ENST00000456850 ENSP00000388967
ENST00000512747
ENST00000482750 ENSP00000421262
ENST00000464642 ENSP00000425233
ENST00000487883 ENSP00000423966
ENST00000473378 ENSP00000423601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004911 interleukin-2 receptor activity
GO:0004913 interleukin-4 receptor activity
GO:0004917 interleukin-7 receptor activity
GO:0005515 protein binding
GO:0019976 interleukin-2 binding
GO:0019982 interleukin-7 binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0035771 interleukin-4-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL2 pathway
IL4 pathway
IL-7 pathway
IL9 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
INOH
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
PID BIOCARTA
Il 2 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
IL2-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
IL4-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000206
HUGO
OMIM
CCDS CCDS14406
HPRD 02391
IMGT
EMBL
GenPept
RNA Seq Atlas