InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL2RG

Summary

InnateDB Gene

IDBG-74884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2RG

Gene Name

interleukin 2 receptor, gamma

Synonyms

CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1

Species

Homo sapiens

Ensembl Gene

ENSG00000147168

Encoded Proteins

IDBP-74886

interleukin 2 receptor, gamma

IDBP-74892

interleukin 2 receptor, gamma

IDBP-375001

interleukin 2 receptor, gamma

IDBP-475891

interleukin 2 receptor, gamma

IDBP-485094

interleukin 2 receptor, gamma

IDBP-484875

interleukin 2 receptor, gamma

IDBP-485223

interleukin 2 receptor, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 8041779

IL2RG physically associates with JAK2, suggesting that regulation of JAK2 may be linked to IL2 induced signal transduction.

Entrez Gene

Summary

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:71107404-71112108

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000374202	ENSP00000363318
ENST00000276110
ENST00000374188	ENSP00000363303
ENST00000456850	ENSP00000388967
ENST00000512747
ENST00000482750	ENSP00000421262
ENST00000464642	ENSP00000425233
ENST00000487883	ENSP00000423966
ENST00000473378	ENSP00000423601

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004911	interleukin-2 receptor activity
GO:0004913	interleukin-4 receptor activity
GO:0004917	interleukin-7 receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding
GO:0019982	interleukin-7 binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0035771	interleukin-4-mediated signaling pathway
GO:0038110	interleukin-2-mediated signaling pathway
GO:0038111	interleukin-7-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane