InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A12

Summary

InnateDB Gene

IDBG-74991.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A12

Gene Name

solute carrier family 25 (aspartate/glutamate carrier), member 12

Synonyms

AGC1; ARALAR

Species

Homo sapiens

Ensembl Gene

ENSG00000115840

Encoded Proteins

IDBP-74993

solute carrier family 25 (mitochondrial carrier, Aralar), member 12

IDBP-387544

solute carrier family 25 (mitochondrial carrier, Aralar), member 12

IDBP-387548

solute carrier family 25 (mitochondrial carrier, Aralar), member 12

IDBP-591910

solute carrier family 25 (mitochondrial carrier, Aralar), member 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:171784370-171999859

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000263812	ENSP00000263812
ENST00000422440	ENSP00000388658
ENST00000426896	ENSP00000413968
ENST00000472070
ENST00000494892
ENST00000485880
ENST00000475360	ENSP00000437845
ENST00000472748
ENST00000484227
ENST00000464063

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005509	calcium ion binding
GO:0015183	L-aspartate transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0015810	aspartate transport
GO:0015813	L-glutamate transport
GO:0043490	malate-aspartate shuttle
GO:0044281	small molecule metabolic process
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport