Version 5.4
Homo sapiens Gene: TOP1
Summary
InnateDB Gene IDBG-75139.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP1
Gene Name topoisomerase (DNA) I
Synonyms TOPI
Species Homo sapiens
Ensembl Gene ENSG00000198900
Encoded Proteins
IDBP-75141
topoisomerase (DNA) I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:41028818-41124487
Strand Forward strand
Band q12
Transcripts
ENST00000361337 ENSP00000354522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 166 [view]
Protein-Protein 160 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0012501 programmed cell death
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0040016 embryonic cleavage
GO:0042493 response to drug
Cellular Component
GO:0000228 nuclear chromosome
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0031298 replication fork protection complex
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070544
View Gene Order
ENSBTAG00000007960
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt P11387
TrEMBL Q9BVT2
UniProt Splice Variant
Entrez Gene 7150
UniGene Hs.472737
RefSeq NM_003286
HUGO HGNC:11986
OMIM 126420
CCDS CCDS13312
HPRD
IMGT
EMBL AK292943 AL022394 AL035652 BC000943 CH471077 J03250 M27913 M60688 M60689 M60690 M60691 M60692 M60693 M60694 M60695 M60696 M60697 M60698 M60699 M60700 M60701 M60702 M60703 M60704 M60705 M60706 U07804 U07806 X16479 X52601
GenPept AAA61206 AAA61207 AAA61208 AAB60379 AAB60380 AAH00943 BAF85632 CAA34500 CAA36834 CAI19767 CAI42886 EAW75994 EAW75995
RNA Seq Atlas 7150

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca