Homo sapiens Gene: PLCG1
Summary
InnateDB Gene IDBG-75238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCG1
Gene Name phospholipase C, gamma 1
Synonyms NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1;
Species Homo sapiens
Ensembl Gene ENSG00000124181
Encoded Proteins
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:41136960-41196787
Strand Forward strand
Band q12
Transcripts
ENST00000373271 ENSP00000362368
ENST00000244007 ENSP00000244007
ENST00000423733
ENST00000490253
ENST00000483646
ENST00000492148
ENST00000470528
ENST00000473632
ENST00000465571
ENST00000477870
ENST00000483175
ENST00000461641
ENST00000599785 ENSP00000468958
ENST00000617873
ENST00000619272
ENST00000612731
ENST00000608689
ENST00000608885 ENSP00000476432
ENST00000609821
ENST00000609257 ENSP00000476757
ENST00000607954 ENSP00000476454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 237 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 237 [view]
Protein-Protein 236 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005057 receptor signaling protein activity
GO:0005168 neurotrophin TRKA receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0019901 protein kinase binding
GO:0030971 receptor tyrosine kinase binding
GO:0035254 glutamate receptor binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001701 in utero embryonic development
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009395 phospholipid catabolic process
GO:0010634 positive regulation of epithelial cell migration
GO:0016032 viral process
GO:0016042 lipid catabolic process
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019722 calcium-mediated signaling
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045766 positive regulation of angiogenesis
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0030027 lamellipodium
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Phospholipase C-mediated cascade pathway
PECAM1 interactions pathway
TCR signaling pathway
DAP12 signaling pathway
Antiviral mechanism by IFN-stimulated genes pathway
Signaling by constitutively active EGFR pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Role of phospholipids in phagocytosis pathway
Frs2-mediated activation pathway
PLC-gamma1 signalling pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
DAG and IP3 signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
Netrin-1 signaling pathway
Adaptive Immune System pathway
Immune System pathway
Role of second messengers in netrin-1 signaling pathway
Downstream signal transduction pathway
VEGFR2 mediated cell proliferation pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
ISG15 antiviral mechanism pathway
Inositol phosphate metabolism pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Metabolism pathway
Generation of second messenger molecules pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
PLCG1 events in ERBB2 signaling pathway
Cell surface interactions at the vascular wall pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
Synthesis of IP3 and IP4 in the cytosol pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
VEGF signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Pathways in cancer pathway
Glioma pathway
Non-small cell lung cancer pathway
INOH
NGF signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Ionomycin and phorbal ester signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Epo signaling pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Phospholipase c signaling pathway [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Pertussis toxin-insensitive ccr5 signaling in macrophage [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
EPHA forward signaling
TCR signaling in na´ve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
S1P1 pathway
LPA receptor mediated events
Netrin-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Signaling events mediated by focal adhesion kinase
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
S1P4 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Regulation of CDC42 activity
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
E-cadherin signaling in keratinocytes
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.268177 Hs.610381 Hs.618187
RefSeq NM_002660 NM_182811
HUGO
OMIM
CCDS CCDS13313 CCDS13314
HPRD 01398
IMGT
EMBL
GenPept
RNA Seq Atlas