Homo sapiens Gene: WIPF1
Summary
InnateDB Gene IDBG-75459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WIPF1
Gene Name WAS/WASL interacting protein family, member 1
Synonyms PRPL-2; WASPIP; WIP;
Species Homo sapiens
Ensembl Gene ENSG00000115935
Encoded Proteins
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
WAS/WASL interacting protein family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:174559572-174682916
Strand Reverse strand
Band q31.1
Transcripts
ENST00000272746 ENSP00000272746
ENST00000359761 ENSP00000352802
ENST00000392547 ENSP00000376330
ENST00000392546 ENSP00000376329
ENST00000409891 ENSP00000386431
ENST00000409415 ENSP00000387150
ENST00000410117 ENSP00000386757
ENST00000455428 ENSP00000391785
ENST00000436221 ENSP00000388454
ENST00000467149
ENST00000480400
ENST00000470752
ENST00000474332
ENST00000488830
ENST00000490887
ENST00000469002
ENST00000487291
ENST00000610916 ENSP00000479992
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005522 profilin binding
Biological Process
GO:0006461 protein complex assembly
GO:0008154 actin polymerization or depolymerization
GO:0030048 actin filament-based movement
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0051707 response to other organism
Cellular Component
GO:0001726 ruffle
GO:0005829 cytosol
GO:0005884 actin filament
GO:0015629 actin cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
TCR pathway
TSLP pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Innate Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL C9JB04
UniProt Splice Variant
Entrez Gene 7456
UniGene Hs.128067 Hs.736483
RefSeq NM_001077269 NM_003387 XM_006712727
HUGO HGNC:12736
OMIM 602357
CCDS CCDS2260
HPRD 03835
IMGT
EMBL AC010894 AC104595
GenPept
RNA Seq Atlas 7456