InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WIPF1

Summary

InnateDB Gene

IDBG-75459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WIPF1

Gene Name

WAS/WASL interacting protein family, member 1

Synonyms

PRPL-2; WASPIP; WIP

Species

Homo sapiens

Ensembl Gene

ENSG00000115935

Encoded Proteins

IDBP-75461

WAS/WASL interacting protein family, member 1

IDBP-75463

WAS/WASL interacting protein family, member 1

IDBP-245438

WAS/WASL interacting protein family, member 1

IDBP-245440

WAS/WASL interacting protein family, member 1

IDBP-293580

WAS/WASL interacting protein family, member 1

IDBP-293572

WAS/WASL interacting protein family, member 1

IDBP-293579

WAS/WASL interacting protein family, member 1

IDBP-387692

WAS/WASL interacting protein family, member 1

IDBP-387694

WAS/WASL interacting protein family, member 1

IDBP-812151

WAS/WASL interacting protein family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:174559572-174682916

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000272746	ENSP00000272746
ENST00000359761	ENSP00000352802
ENST00000392547	ENSP00000376330
ENST00000392546	ENSP00000376329
ENST00000409891	ENSP00000386431
ENST00000409415	ENSP00000387150
ENST00000410117	ENSP00000386757
ENST00000455428	ENSP00000391785
ENST00000436221	ENSP00000388454
ENST00000467149
ENST00000480400
ENST00000470752
ENST00000474332
ENST00000488830
ENST00000490887
ENST00000469002
ENST00000487291
ENST00000610916	ENSP00000479992

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding

Biological Process

GO:0006461	protein complex assembly
GO:0008154	actin polymerization or depolymerization
GO:0030048	actin filament-based movement
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0051707	response to other organism

Cellular Component

GO:0001726	ruffle
GO:0005829	cytosol
GO:0005884	actin filament
GO:0015629	actin cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000075284

View Gene Order

ENSBTAG00000001585

Not yet available

Pathways

NETPATH

NetPath_6

KitReceptor pathway

NetPath_11

TCR pathway

NetPath_24

TSLP pathway

REACTOME

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

KEGG

INOH

PID NCI

fcer1pathway

Fc-epsilon receptor I signaling in mast cells

Cross-References

SwissProt

TrEMBL

C9JTB9 E9PB87

UniProt Splice Variant

Entrez Gene

7456

UniGene

Hs.128067 Hs.736483

RefSeq

NM_001077269 NM_003387 XM_006712727

HUGO

HGNC:12736

OMIM

602357

CCDS

CCDS2260

HPRD

03835

IMGT

EMBL

AC010894 AC104595

GenPept

RNA Seq Atlas

7456