InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FEZ1

Summary

InnateDB Gene

IDBG-75464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FEZ1

Gene Name

fasciculation and elongation protein zeta 1 (zygin I)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000149557

Encoded Proteins

IDBP-75466

fasciculation and elongation protein zeta 1 (zygin I)

IDBP-384418

fasciculation and elongation protein zeta 1 (zygin I)

IDBP-586301

fasciculation and elongation protein zeta 1 (zygin I)

IDBP-598011

fasciculation and elongation protein zeta 1 (zygin I)

IDBP-718602

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:125445745-125496317

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000278919	ENSP00000278919
ENST00000366139	ENSP00000393425
ENST00000392709
ENST00000526507
ENST00000527350
ENST00000524427
ENST00000530096
ENST00000528863
ENST00000532778
ENST00000533294
ENST00000534022
ENST00000532981
ENST00000524435	ENSP00000431521
ENST00000527534	ENSP00000434803
ENST00000577924	ENSP00000463116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0043015	gamma-tubulin binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006810	transport
GO:0007155	cell adhesion
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0010976	positive regulation of neuron projection development
GO:0045666	positive regulation of neuron differentiation
GO:0051654	establishment of mitochondrion localization
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0030424	axon
GO:0030425	dendrite
GO:0042995	cell projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032118

View Gene Order

ENSBTAG00000009124

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

9638

UniGene

Hs.224008 Hs.732083

RefSeq

NM_005103 NM_022549 XM_005271734 XM_005271735

HUGO

HGNC:3659

OMIM

604825

CCDS

CCDS31716 CCDS44758

HPRD

09212

IMGT

EMBL

GenPept

RNA Seq Atlas

9638