Homo sapiens Gene: FEZ1
Summary
InnateDB Gene IDBG-75464.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEZ1
Gene Name fasciculation and elongation protein zeta 1 (zygin I)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149557
Encoded Proteins
fasciculation and elongation protein zeta 1 (zygin I)
fasciculation and elongation protein zeta 1 (zygin I)
fasciculation and elongation protein zeta 1 (zygin I)
fasciculation and elongation protein zeta 1 (zygin I)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:125445745-125496317
Strand Reverse strand
Band q24.2
Transcripts
ENST00000278919 ENSP00000278919
ENST00000366139 ENSP00000393425
ENST00000392709
ENST00000526507
ENST00000527350
ENST00000524427
ENST00000530096
ENST00000528863
ENST00000532778
ENST00000533294
ENST00000534022
ENST00000532981
ENST00000524435 ENSP00000431521
ENST00000527534 ENSP00000434803
ENST00000577924 ENSP00000463116
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 77 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006810 transport
GO:0007155 cell adhesion
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0010976 positive regulation of neuron projection development
GO:0045666 positive regulation of neuron differentiation
GO:0051654 establishment of mitochondrion localization
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0030425 dendrite
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL E9PNH2
UniProt Splice Variant
Entrez Gene 9638
UniGene Hs.224008 Hs.732083
RefSeq NM_005103 NM_022549 XM_005271735 XM_005271734
HUGO HGNC:3659
OMIM 604825
CCDS CCDS31716 CCDS44758
HPRD 09212
IMGT
EMBL AP000708
GenPept
RNA Seq Atlas 9638