Homo sapiens Gene: GADD45G
Summary
InnateDB Gene IDBG-75478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GADD45G
Gene Name growth arrest and DNA-damage-inducible, gamma
Synonyms CR6; DDIT2; GADD45gamma; GRP17;
Species Homo sapiens
Ensembl Gene ENSG00000130222
Encoded Proteins
growth arrest and DNA-damage-inducible, gamma
growth arrest and DNA-damage-inducible, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89605013-89606555
Strand Forward strand
Band q22.2
Transcripts
ENST00000252506 ENSP00000252506
ENST00000375769 ENSP00000364924
ENST00000494726
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 90 [view]
Protein-Protein 86 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0000186 activation of MAPKK activity
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:1900745 positive regulation of p38MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
Cell cycle pathway
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
IL12-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006705
HUGO
OMIM
CCDS CCDS6686
HPRD 05383
IMGT
EMBL
GenPept
RNA Seq Atlas