Version 5.4
Homo sapiens Gene: SYK
Summary
InnateDB Gene IDBG-75571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYK
Gene Name spleen tyrosine kinase
Synonyms p72-Syk
Species Homo sapiens
Ensembl Gene ENSG00000165025
Encoded Proteins
IDBP-75573
spleen tyrosine kinase
IDBP-75575
spleen tyrosine kinase
IDBP-75577
spleen tyrosine kinase
IDBP-75579
spleen tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26032420
Antibody-dependent enhancement (ADE) of Dengue virus serotype 2 (DENV-2) elevates mature IL1B secretion via SYK signalling pathway in primary monocytes.
InnateDB Annotation from Orthologs
Summary
PMID 22031919
[Mus musculus] Sykb promotes wound healing in human rhinovirus-infected airway epithelial cells. (Demonstrated in human)
PMID 14699155
[Mus musculus] SYK is a tyrosine protein kinase that is an upstream activator of c-Jun N-terminal kinase (JNK).
PMID 16449524
[Mus musculus] SYK interacts with PLCG2 and plays a role in complement mediated phagocytosis by regulating both actin dynamics and the RhoA activation pathway.
PMID 19151749
[Mus musculus] SYK interacts with TRAF-interacting protein (TIRAP), two proteins with opposing effects on tumour necrosis factor (TNF) signalling where SYK enhances the activation of NF-kappaB by TNF and this is antagonized by TIRAP.
PMID 19339971
[Mus musculus] SYK operating downstream of ITAM-coupled fungal pattern recognition receptors by controlling both pro-IL-1beta synthesis and inflammasome activation after fungal infection.
PMID 19913447
[Mus musculus] SYK and MYD88 adaptor protein pathways activation by bacteria promotes regulatory properties of neutrophils.
PMID 20401526
[Mus musculus] SYK is activated by several ITAM-containing or ITAM-coupled C-type lectin receptors on myeloid cells leading to the production of pro-inflammatory cytokines including IL-1-beta to initiate antifungal responses.
PMID 22031919
[Mus musculus] SYK promotes wound healing in human rhinovirus-infected airway epithelial cells.
PMID 24185614
[Mus musculus] Phosphorylation of the inflammasome adaptor Pycard (ASC) controls inflammasome activity through the formation of ASC specks. The NLRP3 and AIM2 inflammasomes require Syk and Mapk8 (JNK) for their full activity .
PMID 24212132
[Mus musculus] The expression of Clec4e (Mincle) and its downstream signal phospho-Syk/Syk increases after cerebral ischemia and reperfusion.
Entrez Gene
Summary This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:90801787-90898549
Strand Forward strand
Band q22.2
Transcripts
ENST00000375754 ENSP00000364907
ENST00000375751 ENSP00000364904
ENST00000375747 ENSP00000364899
ENST00000375746 ENSP00000364898
ENST00000476708
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 173 [view]
Protein-Protein 170 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001820 serotonin secretion
GO:0001945 lymph vessel development
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0002283 neutrophil activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002554 serotonin secretion by platelet
GO:0006468 protein phosphorylation
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0009887 organ morphogenesis
GO:0010543 regulation of platelet activation
GO:0016032 viral process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019370 leukotriene biosynthetic process
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0032928 regulation of superoxide anion generation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042742 defense response to bacterium
GO:0043306 positive regulation of mast cell degranulation
GO:0043313 regulation of neutrophil degranulation
GO:0043366 beta selection
GO:0045087 innate immune response (InnateDB)
GO:0045401 positive regulation of interleukin-3 biosynthetic process
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045780 positive regulation of bone resorption
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048514 blood vessel morphogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050853 B cell receptor signaling pathway
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071226 cellular response to molecule of fungal origin
GO:0090237 regulation of arachidonic acid secretion
GO:0090330 regulation of platelet aggregation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0019815 B cell receptor complex
GO:0032009 early phagosome
GO:0042101 T cell receptor complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021457
View Gene Order
ENSBTAG00000004767
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_21
RANKL pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_160274
FCGR activation pathway
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
nfkappabatypicalpathway
Atypical NF-kappaB pathway
alphasynuclein_pathway
Alpha-synuclein signaling
txa2pathway
Thromboxane A2 receptor signaling
il2_1pathway
IL2-mediated signaling events
bcr_5pathway
BCR signaling pathway
gmcsf_pathway
GMCSF-mediated signaling events
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
avb3_opn_pathway
Osteopontin-mediated events
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt P43405
TrEMBL A0A024R244 A0A024R273
UniProt Splice Variant
Entrez Gene 6850
UniGene Hs.371720
RefSeq NM_001135052 NM_001174167 NM_001174168 NM_003177 XM_005252147
HUGO HGNC:11491
OMIM 600085
CCDS CCDS47992 CCDS6688
HPRD
IMGT
EMBL AL354862 BC001645 BC002962 BC011399 CH471089 L28824 X73568 Z29630
GenPept AAA36526 AAH01645 AAH02962 AAH11399 CAA51970 CAA82737 EAW62782 EAW62783 EAW62784 EAW62785 EAW62786
RNA Seq Atlas 6850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca