Version 5.4
Homo sapiens Gene: ATF2
Summary
InnateDB Gene IDBG-75609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF2
Gene Name activating transcription factor 2
Synonyms CRE-BP1; CREB-2; CREB2; HB16; TREB7
Species Homo sapiens
Ensembl Gene ENSG00000115966
Encoded Proteins
IDBP-75611
activating transcription factor 2
IDBP-75613
activating transcription factor 2
IDBP-245446
activating transcription factor 2
IDBP-293539
activating transcription factor 2
IDBP-293531
activating transcription factor 2
IDBP-293537
activating transcription factor 2
IDBP-293529
activating transcription factor 2
IDBP-387715
activating transcription factor 2
IDBP-387716
activating transcription factor 2
IDBP-387717
activating transcription factor 2
IDBP-387718
activating transcription factor 2
IDBP-387719
activating transcription factor 2
IDBP-387720
activating transcription factor 2
IDBP-387721
activating transcription factor 2
IDBP-387722
activating transcription factor 2
IDBP-387723
activating transcription factor 2
IDBP-387724
activating transcription factor 2
IDBP-583621
activating transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25368329
SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.
Entrez Gene
Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell\'s DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:175072250-175168382
Strand Reverse strand
Band q31.1
Transcripts
ENST00000345739 ENSP00000340576
ENST00000264110 ENSP00000264110
ENST00000392544 ENSP00000376327
ENST00000409499 ENSP00000386282
ENST00000409437 ENSP00000386326
ENST00000409635 ENSP00000387093
ENST00000409833 ENSP00000386526
ENST00000428760 ENSP00000412293
ENST00000415955 ENSP00000410086
ENST00000456655 ENSP00000402190
ENST00000426833 ENSP00000407911
ENST00000421438 ENSP00000410224
ENST00000429579 ENSP00000402229
ENST00000417080 ENSP00000389504
ENST00000435004 ENSP00000406995
ENST00000437522 ENSP00000416854
ENST00000435231 ENSP00000414171
ENST00000413123
ENST00000445349
ENST00000478905
ENST00000538946 ENSP00000437952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 387 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 387 [view]
Protein-Protein 235 [view]
Protein-DNA 152 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
GO:0019901 protein kinase binding
GO:0035497 cAMP response element binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003151 outflow tract morphogenesis
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006970 response to osmotic stress
GO:0006974 cellular response to DNA damage stimulus
GO:0016573 histone acetylation
GO:0031573 intra-S DNA damage checkpoint
GO:0032915 positive regulation of transforming growth factor beta2 production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0060612 adipose tissue development
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027104
View Gene Order
ENSBTAG00000002295
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_24941
Circadian Clock pathway
REACT_172610
HATs acetylate histones pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
il12_2pathway
IL12-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
ap1_pathway
AP-1 transcription factor network
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL F2Z2K2
UniProt Splice Variant
Entrez Gene 1386
UniGene Hs.714996
RefSeq NM_001256090 NM_001256091 NM_001256092 NM_001256093 NM_001256094 NM_001880
HUGO HGNC:784
OMIM 123811
CCDS CCDS2262 CCDS58737 CCDS58738 CCDS58739
HPRD 00443
IMGT
EMBL AC007435 AC074291 AC096649 AC131958
GenPept
RNA Seq Atlas 1386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca