InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP5G3

Summary

InnateDB Gene

IDBG-75631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5G3

Gene Name

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000154518

Encoded Proteins

IDBP-75633

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

IDBP-245452

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

IDBP-293530

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:175176258-175184607

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000284727	ENSP00000284727
ENST00000392541	ENSP00000376324
ENST00000409194	ENSP00000387317
ENST00000497075
ENST00000472782

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008289	lipid binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport

Cellular Component

GO:0005739	mitochondrion
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016021	integral component of membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018770

View Gene Order

ENSBTAG00000002944

Not yet available

Pathways

NETPATH

REACTOME

REACT_6759

Formation of ATP by chemiosmotic coupling pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

P48201

TrEMBL

UniProt Splice Variant

Entrez Gene

518

UniGene

Hs.534102 Hs.708491

RefSeq

NM_001689 NM_001002258

HUGO

HGNC:843

OMIM

602736

CCDS

CCDS2263

HPRD

04112

IMGT

EMBL

AC096649 AK311999 BC106881 CH471058 U09813

GenPept

AAA78807 AAI06882 AAX88970 BAG34937 EAX11106 EAX11107

RNA Seq Atlas

518