Version 5.4
Homo sapiens Gene: SGK2
Summary
InnateDB Gene IDBG-75934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGK2
Gene Name serum/glucocorticoid regulated kinase 2
Synonyms dJ138B7.2; H-SGK2
Species Homo sapiens
Ensembl Gene ENSG00000101049
Encoded Proteins
IDBP-75936
serum/glucocorticoid regulated kinase 2
IDBP-75940
serum/glucocorticoid regulated kinase 2
IDBP-75942
serum/glucocorticoid regulated kinase 2
IDBP-75946
serum/glucocorticoid regulated kinase 2
IDBP-375702
serum/glucocorticoid regulated kinase 2
IDBP-375707
serum/glucocorticoid regulated kinase 2
IDBP-375712
serum/glucocorticoid regulated kinase 2
IDBP-601434
serum/glucocorticoid regulated kinase 2
IDBP-809690
serum/glucocorticoid regulated kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:43558968-43588237
Strand Forward strand
Band q13.12
Transcripts
ENST00000373100 ENSP00000362192
ENST00000373092 ENSP00000362184
ENST00000373077 ENSP00000362168
ENST00000341458 ENSP00000340608
ENST00000423407 ENSP00000392795
ENST00000412111 ENSP00000396222
ENST00000426287 ENSP00000412214
ENST00000496343 ENSP00000436841
ENST00000485914
ENST00000617268 ENSP00000481432
ENST00000617358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0015459 potassium channel regulator activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017080 sodium channel regulator activity
Biological Process
GO:0001558 regulation of cell growth
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0032411 positive regulation of transporter activity
GO:0034220 ion transmembrane transport
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell proliferation
GO:0055085 transmembrane transport
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017868
View Gene Order
ENSBTAG00000021033
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9HBY8
TrEMBL X6R8H3
UniProt Splice Variant
Entrez Gene 10110
UniGene Hs.300863 Hs.598045 Hs.599911
RefSeq NM_001199264 NM_016276 NM_170693
HUGO HGNC:13900
OMIM 607589
CCDS CCDS13321 CCDS13320
HPRD 06348
IMGT
EMBL AF169034 AF186470 AY987010 BC014037 BC065511 BT020098 Z98752
GenPept AAF12757 AAG17012 AAH14037 AAH65511 AAV38901 AAX88805 CAC18509 CAI42312 CAI42315
RNA Seq Atlas 10110

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca