Version 5.4
Homo sapiens Gene: OGT
Summary
InnateDB Gene IDBG-76196.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGT
Gene Name O-linked N-acetylglucosamine (GlcNAc) transferase
Synonyms HRNT1; O-GLCNAC
Species Homo sapiens
Ensembl Gene ENSG00000147162
Encoded Proteins
IDBP-76198
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
IDBP-76202
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
IDBP-375544
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
IDBP-375547
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:71533083-71575897
Strand Forward strand
Band q13.1
Transcripts
ENST00000373719 ENSP00000362824
ENST00000373701 ENSP00000362805
ENST00000444774 ENSP00000399729
ENST00000455587 ENSP00000407659
ENST00000488174
ENST00000472270
ENST00000498566
ENST00000459760
ENST00000462638
ENST00000466181
ENST00000474633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008047 enzyme activator activity
GO:0008375 acetylglucosaminyltransferase activity
GO:0016262 protein N-acetylglucosaminyltransferase activity
GO:0042802 identical protein binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
GO:0097363 protein O-GlcNAc transferase activity
Biological Process
GO:0006110 regulation of glycolytic process
GO:0006325 chromatin organization
GO:0006493 protein O-linked glycosylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007584 response to nutrient
GO:0030854 positive regulation of granulocyte differentiation
GO:0031397 negative regulation of protein ubiquitination
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0035020 regulation of Rac protein signal transduction
GO:0043085 positive regulation of catalytic activity
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045862 positive regulation of proteolysis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046626 regulation of insulin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
GO:0071300 cellular response to retinoic acid
GO:0080182 histone H3-K4 trimethylation
GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070688 MLL5-L complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034160
View Gene Order
ENSBTAG00000000902
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.405410 Hs.705676 Hs.717682
RefSeq NM_181672 NM_181673
HUGO
OMIM
CCDS CCDS14414 CCDS35502
HPRD 02222
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca