Homo sapiens Gene: RPS4X
Summary
InnateDB Gene IDBG-76537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS4X
Gene Name ribosomal protein S4, X-linked
Synonyms CCG2; DXS306; RPS4; S4; SCAR; SCR10;
Species Homo sapiens
Ensembl Gene ENSG00000198034
Encoded Proteins
ribosomal protein S4, X-linked
ribosomal protein S4, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:72255679-72277300
Strand Reverse strand
Band q13.1
Transcripts
ENST00000316084 ENSP00000362744
ENST00000373626 ENSP00000362729
ENST00000470671
ENST00000492695
ENST00000486733
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 194 [view]
Protein-Protein 194 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
GO:0045727 positive regulation of translation
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005844 polysome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Translation initiation complex formation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P62701
TrEMBL A6NH36 B2R491 Q96IR1
UniProt Splice Variant
Entrez Gene 6191
UniGene Hs.534081 Hs.641895 Hs.668202 Hs.734667
RefSeq NM_001007
HUGO HGNC:10424
OMIM 312760
CCDS CCDS14418
HPRD
IMGT
EMBL AF041428 AK097914 AK311745 AL135749 BC000472 BC007308 BC071662 BC100903 BC100904 CH471213 CR456735 M22146 M58458 Z70767
GenPept AAA36597 AAA63255 AAB96968 AAH00472 AAH07308 AAH71662 AAI00904 AAI00905 BAG34688 BAG53549 CAA94808 CAG33016 EAW71817
RNA Seq Atlas 6191