InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADA

Summary

InnateDB Gene

IDBG-76830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADA

Gene Name

adenosine deaminase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000196839

Encoded Proteins

IDBP-76832

adenosine deaminase

IDBP-587055

adenosine deaminase

IDBP-594126

adenosine deaminase

IDBP-593726

adenosine deaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:44619522-44652233

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000372874	ENSP00000361965
ENST00000464097
ENST00000492931
ENST00000536532	ENSP00000440946
ENST00000539235	ENSP00000446464
ENST00000537820	ENSP00000441818
ENST00000545776
ENST00000536076
ENST00000535573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001883	purine nucleoside binding
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019239	deaminase activity

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001821	histamine secretion
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001890	placenta development
GO:0002314	germinal center B cell differentiation
GO:0002636	positive regulation of germinal center formation
GO:0002686	negative regulation of leukocyte migration
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006144	purine nucleobase metabolic process
GO:0006154	adenosine catabolic process
GO:0006157	deoxyadenosine catabolic process
GO:0007155	cell adhesion
GO:0007568	aging
GO:0008152	metabolic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0010460	positive regulation of heart rate
GO:0030324	lung development
GO:0030890	positive regulation of B cell proliferation
GO:0032261	purine nucleotide salvage
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0033197	response to vitamin E
GO:0033632	regulation of cell-cell adhesion mediated by integrin
GO:0042110	T cell activation
GO:0042323	negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043066	negative regulation of apoptotic process
GO:0043101	purine-containing compound salvage
GO:0043103	hypoxanthine salvage
GO:0043278	response to morphine
GO:0044281	small molecule metabolic process
GO:0045187	regulation of circadian sleep/wake cycle, sleep
GO:0045580	regulation of T cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045987	positive regulation of smooth muscle contraction
GO:0046061	dATP catabolic process
GO:0046101	hypoxanthine biosynthetic process
GO:0046103	inosine biosynthetic process
GO:0046111	xanthine biosynthetic process
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0048286	lung alveolus development
GO:0048541	Peyer's patch development
GO:0048566	embryonic digestive tract development
GO:0050728	negative regulation of inflammatory response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0060169	negative regulation of adenosine receptor signaling pathway
GO:0060407	negative regulation of penile erection
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0070256	negative regulation of mucus secretion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030054	cell junction
GO:0032839	dendrite cytoplasm
GO:0043025	neuronal cell body
GO:0060205	cytoplasmic membrane-bounded vesicle lumen