Homo sapiens Gene: HSD17B3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-77323.5 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | HSD17B3 | ||||||||||||||
Gene Name | hydroxysteroid (17-beta) dehydrogenase 3 | ||||||||||||||
Synonyms | EDH17B3; SDR12C2 | ||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Gene | ENSG00000130948 | ||||||||||||||
Encoded Proteins |
hydroxysteroid (17-beta) dehydrogenase 3
hydroxysteroid (17-beta) dehydrogenase 3
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008] This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 9:96235306-96302152 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | q22.32 | ||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Androgen biosynthesis pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism of steroid hormones and vitamin D pathway
Metabolism pathway
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KEGG |
Steroid hormone biosynthesis pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Hs.477 | ||||||||||||||
RefSeq | NM_000197 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS6716 | ||||||||||||||
HPRD | 05716 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||