Version 5.4
Homo sapiens Gene: GLS
Summary
InnateDB Gene IDBG-77587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLS
Gene Name glutaminase
Synonyms AAD20; GAC; GAM; GLS1; KGA
Species Homo sapiens
Ensembl Gene ENSG00000115419
Encoded Proteins
IDBP-77589
glutaminase
IDBP-77591
glutaminase
IDBP-293294
glutaminase
IDBP-293295
glutaminase
IDBP-293289
glutaminase
IDBP-388056
glutaminase
IDBP-388057
glutaminase
IDBP-388058
glutaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:190880827-190965552
Strand Forward strand
Band q32.2
Transcripts
ENST00000320717 ENSP00000317379
ENST00000338435 ENSP00000340689
ENST00000409626 ENSP00000386417
ENST00000409428 ENSP00000387177
ENST00000409215 ENSP00000387135
ENST00000417154 ENSP00000388990
ENST00000457316 ENSP00000395596
ENST00000412247 ENSP00000403329
ENST00000479552
ENST00000496170
ENST00000469774
ENST00000461965
ENST00000468352
ENST00000495444
ENST00000471443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004359 glutaminase activity
GO:0005515 protein binding
Biological Process
GO:0001967 suckling behavior
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006537 glutamate biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006543 glutamine catabolic process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0008652 cellular amino acid biosynthetic process
GO:0014047 glutamate secretion
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026103
View Gene Order
ENSBTAG00000007863
Not yet available
Pathways
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00471
D-Glutamine and D-glutamate metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601314 Hs.607441 Hs.621752 Hs.624629 Hs.707400
RefSeq NM_001256310 NM_014905 XM_006712436
HUGO
OMIM
CCDS CCDS2308 CCDS58744
HPRD 00700
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca