Homo sapiens Gene: IKBKE
Summary
InnateDB Gene IDBG-776557.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKBKE
Gene Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Synonyms IKK-E; IKK-i; IKKE; IKKI;
Species Homo sapiens
Ensembl Gene ENSG00000263528
Encoded Proteins
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IKBKE interacts with NKFB2 (p52) and promotes transactivation via RELA (p65)-regulation of the alternative NF-kappaB activation pathway involving p52 and p65.
IKBKE is an IkappaB kinase that is expressed mainly in immune cells, and is induced in response to pro-inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, IL-1-beta and IL-6, in addition to LPS.
IKBKE and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.
IKBKE and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
IKBKE kinase modulates IL-17 signalling through TRAF3IP2 adaptor protein phosphorylation, resulting in the induction of neutrophilia and pulmonary inflammation. (Demonstrated in mouse)
IKBKE is an important signalling molecule in the IFN pathway and is necessary to mount anti-viral immunity against West Nile virus. (Demonstrated in mice)
IKBKE plays a critical role in regulating the balance between the type I and type II interferon (IFN) signalling pathways.
IKBKE is sequestered by arenavirus nucleoproteins to block its autocatalytic activity and its ability to active IRF3.
IKBKE is poly-ubiquitinated at Lys30 and 401 to promote NF-kB activation in macrophages stimulated with TNFA and IL1B.
Entrez Gene
Summary IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30%% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:206470476-206496889
Strand Forward strand
Band q32.1
Transcripts
ENST00000605818
ENST00000578328 ENSP00000473833
ENST00000584998 ENSP00000462396
ENST00000581977 ENSP00000464030
ENST00000579827 ENSP00000474422
ENST00000605726 ENSP00000474229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 132 experimentally validated interaction(s) in this database.
Experimentally validated
Total 132 [view]
Protein-Protein 131 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008384 IkappaB kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007252 I-kappaB phosphorylation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032480 negative regulation of type I interferon production
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016605 PML body
Orthologs
No orthologs found for this gene
Pathways
NETPATH
TNFalpha pathway
REACTOME
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
MyD88-independent cascade pathway
TRAF3-dependent IRF activation pathway pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Negative regulators of RIG-I/MDA5 signaling pathway
KEGG
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001193321 NM_001193322 NM_014002 XM_005273356 XM_006711641
HUGO
OMIM
CCDS CCDS30996 CCDS53464 CCDS73019
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas