Homo sapiens Gene: P4HA1
Summary
InnateDB Gene IDBG-78057.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HA1
Gene Name prolyl 4-hydroxylase, alpha polypeptide I
Synonyms P4HA;
Species Homo sapiens
Ensembl Gene ENSG00000122884
Encoded Proteins
prolyl 4-hydroxylase, alpha polypeptide I
prolyl 4-hydroxylase, alpha polypeptide I
prolyl 4-hydroxylase, alpha polypeptide I
prolyl 4-hydroxylase, alpha polypeptide I
prolyl 4-hydroxylase, alpha polypeptide I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:73007217-73096974
Strand Reverse strand
Band q22.1
Transcripts
ENST00000307116 ENSP00000307318
ENST00000373008 ENSP00000362099
ENST00000263556 ENSP00000263556
ENST00000394890 ENSP00000378353
ENST00000440381 ENSP00000414464
ENST00000464310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199 collagen fibril organization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
GO:0016222 procollagen-proline 4-dioxygenase complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Arginine and proline metabolism pathway
INOH
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P13674
TrEMBL Q5VSQ6
UniProt Splice Variant
Entrez Gene 5033
UniGene
RefSeq NM_000917 NM_001017962 NM_001142595 NM_001142596
HUGO HGNC:8546
OMIM 176710
CCDS CCDS41537 CCDS44432 CCDS7320
HPRD 08901
IMGT
EMBL AK222960 AL731563 BC034998 CD013929 CH471083 M24486 M24487 U14605 U14607 U14608 U14609 U14610 U14611 U14612 U14613 U14614 U14615 U14616 U14617 U14618 U14619 U14620
GenPept AAA36534 AAA36535 AAA59068 AAA59069 AAH34998 BAD96680 CAH72754 EAW54467 EAW54468
RNA Seq Atlas 5033