Homo sapiens Gene: SUMO1
Summary
InnateDB Gene IDBG-78849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUMO1
Gene Name SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
Synonyms DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1;
Species Homo sapiens
Ensembl Gene ENSG00000116030
Encoded Proteins
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:202206180-202238608
Strand Reverse strand
Band q33.1
Transcripts
ENST00000392246 ENSP00000376077
ENST00000392245 ENSP00000376076
ENST00000392244 ENSP00000376075
ENST00000409368 ENSP00000387204
ENST00000409627 ENSP00000386500
ENST00000409712 ENSP00000386296
ENST00000409498 ENSP00000386472
ENST00000409205 ENSP00000386267
ENST00000409181 ENSP00000386753
ENST00000469034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1363 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 1363 [view]
Protein-Protein 1353 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006281 DNA repair
GO:0006355 regulation of transcription, DNA-templated
GO:0016925 protein sumoylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030578 PML body organization
GO:0031334 positive regulation of protein complex assembly
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880 regulation of protein localization
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060021 palate development
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0090204 protein localization to nuclear pore
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0030425 dendrite
GO:0031965 nuclear membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
TNFalpha pathway
REACTOME
Post-translational protein modification pathway
Cytokine Signaling in Immune system pathway
Processing and activation of SUMO pathway
Interferon Signaling pathway
Metabolism of proteins pathway
Immune System pathway
SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway
Interferon gamma signaling pathway
SUMO is conjugated to E1 (UBA2:SAE1) pathway
SUMO is proteolytically processed pathway
SUMOylation pathway
Regulation of IFNG signaling pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Regulation of transcriptional activity by pml [Biocarta view]
Sumoylation by ranbp2 regulates transcriptional repression [Biocarta view]
Basic mechanisms of sumoylation [Biocarta view]
Role of parkin in ubiquitin-proteasomal pathway [Biocarta view]
Sumoylation as a mechanism to modulate ctbp-dependent gene responses [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596171 Hs.635713
RefSeq NM_001005781 NM_001005782 NM_003352
HUGO
OMIM
CCDS CCDS2352 CCDS46493
HPRD 03554
IMGT
EMBL
GenPept
RNA Seq Atlas