Homo sapiens Gene: CD40
Summary
InnateDB Gene IDBG-78904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD40
Gene Name CD40 molecule, TNF receptor superfamily member 5
Synonyms Bp50; CDW40; p50; TNFRSF5;
Species Homo sapiens
Ensembl Gene ENSG00000101017
Encoded Proteins
CD40 molecule, TNF receptor superfamily member 5
CD40 molecule, TNF receptor superfamily member 5
CD40 molecule, TNF receptor superfamily member 5
CD40 molecule, TNF receptor superfamily member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:46118272-46129863
Strand Forward strand
Band q13.12
Transcripts
ENST00000372285 ENSP00000361359
ENST00000372276 ENSP00000361350
ENST00000466205 ENSP00000434825
ENST00000489304
ENST00000477696
ENST00000461171
ENST00000620709 ENSP00000484074
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 64 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004871 signal transducer activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0006461 protein complex assembly
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0030168 platelet activation
GO:0030890 positive regulation of B cell proliferation
GO:0032735 positive regulation of interleukin-12 production
GO:0032855 positive regulation of Rac GTPase activity
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0051023 regulation of immunoglobulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0090037 positive regulation of protein kinase C signaling
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0035631 CD40 receptor complex
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL4 pathway
IL6 pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Cell adhesion molecules (CAMs) pathway
Toll-like receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Malaria pathway
Toxoplasmosis pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Primary immunodeficiency pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
Cd40l signaling pathway [Biocarta view]
PID NCI
CD40/CD40L signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001250 NM_152854 XM_005260617
HUGO
OMIM
CCDS CCDS13393 CCDS13394
HPRD 00178
IMGT
EMBL
GenPept
RNA Seq Atlas