InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD40

Summary

InnateDB Gene

IDBG-78904.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD40

Gene Name

CD40 molecule, TNF receptor superfamily member 5

Synonyms

Bp50; CDW40; p50; TNFRSF5

Species

Homo sapiens

Ensembl Gene

ENSG00000101017

Encoded Proteins

IDBP-78906

CD40 molecule, TNF receptor superfamily member 5

IDBP-78916

CD40 molecule, TNF receptor superfamily member 5

IDBP-590735

CD40 molecule, TNF receptor superfamily member 5

IDBP-810616

CD40 molecule, TNF receptor superfamily member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25549946

[Mus musculus] Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.

Entrez Gene

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:46118272-46129863

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000372285	ENSP00000361359
ENST00000372276	ENSP00000361350
ENST00000466205	ENSP00000434825
ENST00000489304
ENST00000477696
ENST00000461171
ENST00000620709	ENSP00000484074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	64 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0006461	protein complex assembly
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0030168	platelet activation
GO:0030890	positive regulation of B cell proliferation
GO:0032735	positive regulation of interleukin-12 production
GO:0032855	positive regulation of Rac GTPase activity
GO:0042100	B cell proliferation
GO:0042113	B cell activation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0051023	regulation of immunoglobulin secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0090037	positive regulation of protein kinase C signaling
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0035631	CD40 receptor complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017652

View Gene Order

ENSBTAG00000020736

Not yet available

Pathways

NETPATH

NetPath_16

IL4 pathway

NetPath_18

IL6 pathway

REACTOME

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04620

Toll-like receptor signaling pathway pathway

hsa05330

Allograft rejection pathway

hsa05320

Autoimmune thyroid disease pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05340

Primary immunodeficiency pathway

hsa05310

Asthma pathway

hsa04672

Intestinal immune network for IgA production pathway

hsa05416

Viral myocarditis pathway

hsa05144

Malaria pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

cd40_pathway

CD40/CD40L signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001250 NM_152854 XM_005260617

HUGO

OMIM

CCDS

CCDS13393 CCDS13394

HPRD

00178

IMGT

EMBL

GenPept

RNA Seq Atlas