InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BAAT

Summary

InnateDB Gene

IDBG-78917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAAT

Gene Name

bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

Synonyms

BACAT; BAT

Species

Homo sapiens

Ensembl Gene

ENSG00000136881

Encoded Proteins

IDBP-78919

bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

IDBP-240353

bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:101360417-101383519

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000259407	ENSP00000259407
ENST00000395051	ENSP00000378491

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016410	N-acyltransferase activity
GO:0016790	thiolester hydrolase activity
GO:0047963	glycine N-choloyltransferase activity
GO:0052815	medium-chain acyl-CoA hydrolase activity
GO:0052816	long-chain acyl-CoA hydrolase activity
GO:0052817	very long chain acyl-CoA hydrolase activity

Biological Process

GO:0001889	liver development
GO:0002152	bile acid conjugation
GO:0006544	glycine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006699	bile acid biosynthetic process
GO:0008206	bile acid metabolic process
GO:0015721	bile acid and bile salt transport
GO:0019530	taurine metabolic process
GO:0031100	organ regeneration
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000039653

View Gene Order

Pathways

NETPATH

REACTOME

REACT_11041

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway

REACT_11054

Synthesis of bile acids and bile salts pathway

REACT_11042

Recycling of bile acids and salts pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_11040

Bile acid and bile salt metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00430

Taurine and hypotaurine metabolism pathway

hsa01040

Biosynthesis of unsaturated fatty acids pathway

hsa00120

Primary bile acid biosynthesis pathway

hsa04146

Peroxisome pathway

hsa04976

Bile secretion pathway

INOH

INOH website

Methionine Cysteine metabolism pathway

PID NCI

Cross-References

SwissProt

Q14032

TrEMBL

A0A024R149

UniProt Splice Variant

Entrez Gene

570

UniGene

Hs.284712

RefSeq

NM_001701 NM_001127610

HUGO

HGNC:932

OMIM

602938

CCDS

CCDS6752

HPRD

08376

IMGT

EMBL

AL359893 BC009567 BC107424 CH471105 CR541918 L34081

GenPept

AAC37550 AAH09567 AAI07425 CAG46716 CAH72995 EAW58943 EAW58944 EAW58946

RNA Seq Atlas

570