Homo sapiens Gene: ALDOB
Summary
InnateDB Gene IDBG-78994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDOB
Gene Name aldolase B, fructose-bisphosphate
Synonyms ALDB; ALDO2;
Species Homo sapiens
Ensembl Gene ENSG00000136872
Encoded Proteins
aldolase B, fructose-bisphosphate
aldolase B, fructose-bisphosphate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related \'housekeeping\' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5%% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:101420578-101435823
Strand Reverse strand
Band q31.1
Transcripts
ENST00000374855 ENSP00000363988
ENST00000468981
ENST00000616752 ENSP00000481363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0042802 identical protein binding
GO:0051117 ATPase binding
GO:0070061 fructose binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006001 fructose catabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006116 NADH oxidation
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0032781 positive regulation of ATPase activity
GO:0044281 small molecule metabolic process
GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly
Cellular Component
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0034451 centriolar satellite
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Fructose catabolism pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
INOH
Fructose Mannose metabolism pathway
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt P05062
TrEMBL A0A024R145
UniProt Splice Variant
Entrez Gene 229
UniGene
RefSeq NM_000035
HUGO HGNC:417
OMIM 612724
CCDS CCDS6756
HPRD
IMGT
EMBL AL353621 CH471105 D00183 M15656 M15657 X00270 X01098 X02747
GenPept AAA51691 BAA00125 CAA25072 CAA25572 CAA26526 CAI14614 EAW58951 EAW58952
RNA Seq Atlas 229