Homo sapiens Gene: VDAC2
Summary
InnateDB Gene IDBG-79237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC2
Gene Name voltage-dependent anion channel 2
Synonyms POR;
Species Homo sapiens
Ensembl Gene ENSG00000165637
Encoded Proteins
voltage-dependent anion channel 2
voltage-dependent anion channel 2
voltage-dependent anion channel 2
voltage-dependent anion channel 2
voltage-dependent anion channel 2
voltage-dependent anion channel 2
voltage-dependent anion channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75210154-75231448
Strand Forward strand
Band q22.2
Transcripts
ENST00000332211 ENSP00000361686
ENST00000298468 ENSP00000298468
ENST00000313132 ENSP00000361635
ENST00000344036 ENSP00000344876
ENST00000447677 ENSP00000401492
ENST00000413289 ENSP00000389551
ENST00000472137
ENST00000470745
ENST00000475142
ENST00000481876
ENST00000498394
ENST00000468285
ENST00000460044
ENST00000543351 ENSP00000443092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 57 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006820 anion transport
GO:0032272 negative regulation of protein polymerization
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0042645 mitochondrial nucleoid
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Calcium signaling pathway pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL A2A3S1
UniProt Splice Variant
Entrez Gene 7417
UniGene Hs.355927 Hs.605824
RefSeq NM_003375 NM_001184783 NM_001184823 XM_006717961
HUGO HGNC:12672
OMIM 193245
CCDS CCDS7348 CCDS53544
HPRD 01904
IMGT
EMBL AL390034 AL392111
GenPept
RNA Seq Atlas 7417